Faculties of University Bonn: Search
Now showing items 51-60 of 75
N-glycosylation of intrinsic and engineered N-X-S/T motifs by Pichia pastoris can be exploited to ligate the mannose receptor but reveals no gain in immunogenicity per se
(2016-12-22)
Vaccination has the power to eradicate viral diseases and is a promising approach to cure cancer. However, modern vaccination strategies repeatedly fail in inducing a robust cytotoxic CD8+ T cell response, which ...
Study on the role of Cofilin 2 in the brain
(2016-12-22)
Three actin depolymerization factors are expressed in the brain, named Cofilin 1 (non-muscle Cofilin), ADF and Cofilin 2, which was long declared as muscle-specific isoform. All three members share similar biochemical ...
Functional characterization of Cytoplasmic Polyadenylation Element Binding proteins in the developing and diseased brain
(2016-12-22)
Gliomas are the most common primary brain tumors with aggressive progression and devastating prognosis. Therefore identification of new therapeutic and diagnostic factors is necessary to improve the dramatic situation of ...
Click-SELEX: A versatile approach towards nucleobase-modified aptamers
(2016-11-28)
Aptamers are short nucleic acids that can be selected to bind specifically and with high affinity to a variety of targets, including small organic molecules and proteins. However, for a multitude of targets, traditional ...
Identification of protective immune responses and the immunomodulatory capacity of Litomosoides sigmodontis
(2016-11-29)
Using the mouse model Litomosoides sigmodontis, research focusing on the protective immune responses within the host as well as the immunomodulatory capabilities of filarial infections is possible. The immunomodulatory ......
Langzeitergebnisse hinsichtlich Komplikationen bei Patienten mit Leberzirrhose und transjugulären intrahepatischen portosystemischen Shunts (TIPS)
(2016-06-30)
Hintergrund: Die hepatische Enzephalopathie (HE) ist, ebenso wie der Child- und MELD-score bei Patienten mit Leberzirrhose ein zuverlässiger Prädiktor der Mortalität. Dies trifft insbesondere auch für Patienten zu, die ...
Metabolic markers as determinants of future waist-gaining or hip-gaining phenotype in weight-gaining individuals: A targeted metabolomics approach in population-based prospective German cohort studies
(2016-05-31)
Overweight and obesity are major public health problems in Germany. The associated comorbidities are highly depending on individual body fat distribution. A distinction is made between android and gynoid body fat distribution, ...
Regulation of adiponectin expression by trans-cinnamic acid and niacin in murine and bovine adipocytes in vitro
(2016-06-24)
Adipose tissue secretes multiple metabolically important proteins known as adipokines, one of the most abundant is adiponectin (AdipoQ). Known as an important modulator of glucose and fat metabolism, adipoQ is a key regulator ...
Complementary feeding practice during infancy and its relevance for dietary behaviour in infancy and childhood
(2016-06-10)
Emerging research indicates that besides innate taste preferences early sensory experiences in infancy via amniotic fluid, breast milk, and infant formula play a crucial role in the development of individual food preferences ...
Zwischen Innovationsdruck und Ressourcenknappheit: Die Veränderungen studentischer Lehre am Zentrum für Kinderheilkunde Bonn von 2009 bis 2013
(2016-12-01)
Am Zentrum für Kinderheilkunde der Universität Bonn absolvieren Studierende der Humanmedizin mehrere Pflichtveranstaltungen. Seit Beginn der 2000er werden diese Veranstaltungen zentral evaluiert. Entsprechend einem ...