Merz, Benedikt Alexander: Metabolic markers as determinants of future waist-gaining or hip-gaining phenotype in weight-gaining individuals : A targeted metabolomics approach in population-based prospective German cohort studies. - Bonn, 2016. - Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn.
Online-Ausgabe in bonndoc: https://nbn-resolving.org/urn:nbn:de:hbz:5n-43740
@phdthesis{handle:20.500.11811/6614,
urn: https://nbn-resolving.org/urn:nbn:de:hbz:5n-43740,
author = {{Benedikt Alexander Merz}},
title = {Metabolic markers as determinants of future waist-gaining or hip-gaining phenotype in weight-gaining individuals : A targeted metabolomics approach in population-based prospective German cohort studies},
school = {Rheinische Friedrich-Wilhelms-Universität Bonn},
year = 2016,
month = may,

note = {Overweight and obesity are major public health problems in Germany. The associated comorbidities are highly depending on individual body fat distribution. A distinction is made between android and gynoid body fat distribution, which is highly depending on factors like age and sex.
The present thesis aims to investigate general tendencies to one of these distributions using data from 4,126 weight-gaining individuals of three prospective German cohort studies. Furthermore, metabolic determinants for these phenotypes of body fat distribution are investigated based on targeted metabolomics data assessed with the Biocrates AbsoluteIDQTM kits. The difference of average annual changes in waist and hip circumference was calculated to assess the tendency to android or gynoid body fat distribution. Sex-specific extrema-deciles of these differences were used to define waist-gaining and hip-gaining phenotypes, all remaining individuals formed the reference category. Multiple sex-specific logistic regression models adjusted for potential confounders with standardized metabolite concentration as independent and weight-gaining phenotype as dependent variable were fitted. Besides the single metabolite approach, a principal component analysis as a data-reduction method based on quality-controlled metabolite data was performed; corresponding principal components were as well used as independent variables in the pre-described logistic regression model.
Overall, a general tendency to increase rather waist than hip circumference could be observed in men as well as in women. The identification of predictive metabolites showed tryptophan, the diacyl-phosphatidylcholines C32:2, C36:0, C38:0, C38:1, C42:2, C42:5, the acyl-alkyl-phosphatidylcholines C32:2, C34:0, C36:0, C36:1, C36:2, C38:0, C38:2, C40:1, C40:2, C40:5, C40:6, C42:2, C42:3 and lyso-phosphatidylcholine C17:0 to be inversely associated with the waist-gaining phenotype in women. For the waist-gaining phenotype in men and the hip-gaining phenotype in both sexes, no metabolite could be identified to be statistically significantly associated. The principal component analysis revealed biologically plausible principal components, of which one principal component mainly consisting of phosphatidylcholines was inversely associated with the waist-gaining phenotype in both sexes. Metabolites that have been identified to be inversely associated with the waist-gaining phenotype in women before all showed high factor loadings on the associated principal component. The identified or high-loading metabolites were all shown to be associated with favourable health conditions like increased fat free mass index, higher cardiorespiratory fitness, normotensive blood pressure and increased insulin-sensitivity.
Weight-gaining individuals in Germany tend to increase abdominal body fat and especially the group of phosphatidylcholines was observed to be involved. Thus, future studies should investigate their role in future body fat deposition to increase our knowledge of associated pathophysiological pathways.},

url = {http://hdl.handle.net/20.500.11811/6614}
}

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