Fakultäten der Universität Bonn: Suche
Anzeige der Dokumente 341-350 von 395
Application of population, physiologically based, and semi-physiological pharmacokinetic modeling to assess sources of pharmacokinetic variability in individual drugs
(2020-06-05)
Large inter- and intra-individual variability in the response of drugs causes difficulties for clinicians to choose appropriate dosing regimens to target their therapeutic range. While underexposure might cause sub-therapeutic ...
Théorie de Bruhat-Tits, grassmanniennes affines et modèles locaux
(2020-10-02)
Nous développons la théorie de Bruhat-Tits pour les groupes quasi-réductifs sur les corps discrètement valués, henséliens et excellents, qui se quasi-déploient sur l'henselisé strict. Ensuite, cette théorie est appliquée ...
Insights into the salt stress adaptation mechanisms of bread wheat genotypes using a systemic approach
(2020-09-17)
Bread wheat is one of the most important crops for the human diet but the increasing soil salinization is causing yield reductions worldwide. The development of appropriate cultivars requires the elucidation of mechanisms ...
Relevance of cGAMP-mediated bystander cell activation and cooperation of cGAS and TLR signaling in TREX1-related autoimmunity
(2020-11-05)
The aberrant recognition of endogenous nucleic acids by innate immune sensors can trigger a wide range of autoimmune and autoinflammatory conditions, mediated by type I interferons. Laoss-of-function mutations in the three ......
Bedeutung der cGAMP-vermittelten Bystander-Zellaktivierung und der Kooperation von cGAS- und TLR-Signalwegen bei TREX1-assoziierter Autoimmunität
Entwicklung von Autoinflammation und Autoimmune ......
Bedeutung der cGAMP-vermittelten Bystander-Zellaktivierung und der Kooperation von cGAS- und TLR-Signalwegen bei TREX1-assoziierter Autoimmunität
Entwicklung von Autoinflammation und Autoimmune ......
Historical Biogeography and Macroevolution of the Atacama Desert Flora
(2020-09-17)
Located in northern Chile, the Atacama Desert is not only one of the oldest deserts but also one of the driest places on earth with hyperarid conditions prevailing since the Miocene or earlier. Despite the extreme conditions ...
Pharmacokinetic-pharmacodynamic modeling of antibacterial agents in tissues and body fluids
(2020-11-25)
The aim of this thesis was to assess the pharmacokinetic / pharmacodynamics (PK/PD) of anti-bacterial agents in tissues and body fluids through non-linear mixed effects (NLME) modeling.
In the first project, a ...
In the first project, a ...
Das Mikrobiom periimplantärer Läsionen: Der Nachweis dysbiotischer Veränderungen in Assoziation mit dem Schweregrad der Erkrankung
(2020-11-05)
Ziel dieser Arbeit
Diese Querschnittsstudie hat zum Ziel das submuköse Mikrobiom periimplantärer Läsionen in verschiedenen Krankheitsstadien zu analysieren.
Material und Methoden
Diese Querschnittsstudie hat zum Ziel das submuköse Mikrobiom periimplantärer Läsionen in verschiedenen Krankheitsstadien zu analysieren.
Material und Methoden
Diversity of feeding and pollination strategies of Mesozoic beetles
(2020-08-23)
Beetles (Order: Coleoptera) as the most diverse and successful animals on the earth, comprise about 400,000 species, constituting almost 40% of described insects and a quarter of all animal species. They are distributed ......
In situ observations of reaction and transport phenomena during silicate glass corrosion by fluid-cell Raman spectroscopy: Method development and applications
(2020-07-06)
Borosilicate glass is the preferred material for the immobilization of high-level nuclear waste and an important material for various industries. Silicate glasses, however, are prone to corrosion by aqueous solutions, which ......
Direct lineage programming - a tool to generate and analyze human cortical layer specific neurons
(2020-05-14)
Until recently, lineage commitment and differentiation have been considered to be unidirectional and irreversible. This traditional view has dramatically changed with the advent of cellular reprogramming and direct cell ......