Fakultäten der Universität Bonn: Suche
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Immunostimulation of Microglia by ASC Specks and ASC Specks Amyloid β Composites
(2021-10-26)
Die Alzheimer-Krankheit stellt die weltweit häufigste Form der Demenz dar. Die genauen Mechanismen, welche zu ihrer Entstehung führen, sind bis heute nicht vollständig verstanden. Eine wichtige Rolle spielt die Aktivierung ......
Immunostimulation of Microglia by ASC Specks and ASC Specks Amyloid β Composites
Alzheimer’s Disease is the world’s most common cause of dementia. The exact mechanisms causing neurodegeneration ......
Immunostimulation of Microglia by ASC Specks and ASC Specks Amyloid β Composites
Alzheimer’s Disease is the world’s most common cause of dementia. The exact mechanisms causing neurodegeneration ......
Synthesis and structure-activity relationships of CD39 and CD73 inhibitors
(2022-08-13)
Ecto-nucleoside triphosphate diphosphohydrolase-1 (NTPDase1 or CD39) is a member of the membrane-bound ecto-nucleotidase family, which catalyzes the extracellular hydrolysis of pro-inflammatory ATP and pro-thrombotic ADP ......
Hippocampal network and inhibitory neuron dysfunction in age and disease
(2021-10-25)
Aging and Alzheimer’s disease (AD) are two highly intertwined pathological processes. Indeed, one of the highest risk factors for developing AD is age. Mechanistically, it has been suggested that remodeling of inhibitory ......
Inhibitory Circuits of the CA3-Dentate Gyrus System
(2021-11-04)
Neuronal inhibition is an essential feature of all brain areas. Besides controlling the average rate of neuronal firing, it also controls the precise timing of action potentials and mediates several types of network ...
Locus coeruleus modulates locomotor activity via the medial septum and the diagonal band of Broca
(2020-10-02)
The locus coeruleus (LC) is positioned in the brainstem and one of the main sources of norepinephrine in the brain. With its projections throughout the whole brain, the LC plays an important role in regulating the general ...
Funktionelle Untersuchungen des ABC-Transporters ABCG2
(2021-10-15)
Das Phänomen der Multidrug Resistance (MDR) stellt ein bedeutsames Problem bei der Behandlung von Tumoren mit Chemotherapeutika dar. Die ABC-Transporter ABCB1, ABCC1 und ABCG2 sind an der Entstehung der MDR beteiligt. ...
Direct lineage programming - a tool to generate and analyze human cortical layer specific neurons
(2020-05-14)
Until recently, lineage commitment and differentiation have been considered to be unidirectional and irreversible. This traditional view has dramatically changed with the advent of cellular reprogramming and direct cell ......
The role of the transcription factor BCL11A in midbrain dopaminergic neurons
(2022-03-11)
Midbrain dopaminergic (mDA) neurons are located in three midbrain nuclei, the substantia nigra (SN), ventral tegmental area (VTA) and retrorubral field (RRF). mDA neurons are diverse in their developmental origin, their ......
Dopaminerge Neuronen des Mittelhirns (mDA) befinden sich in drei Kerngebieten des Mittelhirns, der Substantia nigra (SN), dem ventralen tegmentalen Areal (VTA) und dem retrorubralen Feld (RRF). mDA-Neurone unterscheiden ......
Dopaminerge Neuronen des Mittelhirns (mDA) befinden sich in drei Kerngebieten des Mittelhirns, der Substantia nigra (SN), dem ventralen tegmentalen Areal (VTA) und dem retrorubralen Feld (RRF). mDA-Neurone unterscheiden ......
Evaluating Novel Vector Control Strategies: Modeling the impact of gene editing for malaria elimination in the Democratic Republic of Congo
(2020-08-06)
The tremendous burden of malaria has led to renewed efforts focusing on malaria elimi-nation in the high burden countries. However, to achieve elimination, novel tools includ-ing driving-Y gene drive mosquitoes may be ...