Faculties of University Bonn: Search
Now showing items 31-40 of 44
Contributions towards a better understanding of millipede phylogenetics and sawfly genomics
(2021-03-11)
A loss of biodiversity on a scale and rate comparable to the great extinction events, as a result of anthropogenic activity, has been documented for plants, animals, and micro-organisms. In order to foster a sustainable ...
Heating Performance and Ammonia Removal of a Single-Stage Bioscrubber Pilot Plant with Integrated Heat Exchanger under Field Conditions
(2021-10-10)
In this study, biological exhaust air treatment was combined with a recuperative heat exchanger in one process stage. The aim of this plant development and testing is not only to reduce ammonia from the exhaust air of pig ...
Modulation der Gαi1/s-Proteinaktivität durch lineare und makrozyklische Peptide
(2021-07-08)
Die vorliegende Dissertation beschäftigt sich mit der Identifizierung und Charakterisierung von peptidischen Modulatoren für die Gαi/s-Proteinaktivität. Die Ga-Untereinheit heterotrimerer G-Proteine ist eine bedeutende ...
Hippocampal network and inhibitory neuron dysfunction in age and disease
(2021-10-25)
Aging and Alzheimer’s disease (AD) are two highly intertwined pathological processes. Indeed, one of the highest risk factors for developing AD is age. Mechanistically, it has been suggested that remodeling of inhibitory ......
Inhibitory Circuits of the CA3-Dentate Gyrus System
(2021-11-04)
Neuronal inhibition is an essential feature of all brain areas. Besides controlling the average rate of neuronal firing, it also controls the precise timing of action potentials and mediates several types of network ...
Optimierung und Charakterisierung eines Zwei-Photonen-Besselstrahl-Lichtscheibenmikroskops
(2021-05-10)
In dieser Arbeit wurde ein existierendes konfokales Zwei-Photonen-Lichtscheibenmikroskop charakterisiert und modifiziert. Das System wurde sowohl für Aufnahmen bei hohen Geschwindigkeiten als auch für Langzeitaufnahmen ......
Synthese, Testung und 3D-QSAR von ABCG2-Inhibitoren
(2021-08-09)
Die Behandlung von Krebserkrankungen baut im Allgemeinen auf verschiedenen Säulen auf, wobei die Chemotherapie eine der wichtigsten Therapiemethoden darstellt. Ein häufiges Versagen der Chemotherapie beruht auf der ......
Synthesis, Investigation and 3D-QSAR Analysis of ABCG2 Inhibitors
Cancer is one of the main causes of death worldwide. Despite the significant development of methods of cancer healing during the ......
Synthesis, Investigation and 3D-QSAR Analysis of ABCG2 Inhibitors
Cancer is one of the main causes of death worldwide. Despite the significant development of methods of cancer healing during the ......
Funktionelle Untersuchungen des ABC-Transporters ABCG2
(2021-10-15)
Das Phänomen der Multidrug Resistance (MDR) stellt ein bedeutsames Problem bei der Behandlung von Tumoren mit Chemotherapeutika dar. Die ABC-Transporter ABCB1, ABCC1 und ABCG2 sind an der Entstehung der MDR beteiligt. ...
The Impact of CD44 and Osteopontin on Hematopoiesis
(2021-10-25)
Hematopoiesis is the process, which enables the replenishment of blood cellular components in mammals throughout their lifespan. Hematopoietic stem cells (HSC), which reside within the bone marrow (BM), are the primary ...
Electrostatic anchoring of SNAP25 to the plasma membrane
(2021-07-21)
Neurotransmission is based on incredibly rapid membrane trafficking cycles, mediating the release of neurotransmitters. The fusion machinery of the well-studied SNARE protein complex ensures the speed and precision of ...