Fakultäten der Universität Bonn: Suche
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Functional characterization of Gαi/s proteins and modulation of their activity by linear and cyclic peptides
(2024-01-30)
Heterotrimeric Gαβγ (guanine nucleotide-binding) proteins serve as molecular switches to activate (“switch on”) or inactivate (“switch off”) diverse intracellular signaling cascades in response to stimulated G protein-coupled ...
Das Cyclodepsipeptid FR900359: Ein Insektizid mit neuem Wirkmechanismus aus Cand. Burkholderia crenata und Chromobacterium vaccinii
(2024-01-16)
Sekundärmetabolite (SM) sind für ihr breites Spektrum an Bioaktivitäten bekannt und daher eine wichtige Quelle für neue Arzneimittelkandidaten. Neben ihrer Relevanz für die Therapie von Erkrankungen sind SM und ihre ......
The cyclic depsipeptide FR900359: An insecticide with a novel mode of action from Cand. Burkholderia crenata and Chromobacterium vaccinii
Secondary metabolites (SM) are known for their broad spectrum ......
The cyclic depsipeptide FR900359: An insecticide with a novel mode of action from Cand. Burkholderia crenata and Chromobacterium vaccinii
Secondary metabolites (SM) are known for their broad spectrum ......
Pulsar Scintillation and Interstellar Lenses
(2024-01-29)
The radio emission of pulsars is scattered within the interstellar medium due to variations of the electron column density. Pulsars are very compact sources of pulsed radiation and, thus, emit spatially coherent radiation ...
Impact of Plant Secondary Metabolites on the Soil Microbiota
(2022-08-26)
This study revealed the impact of 2-benzoxazolinone (BOA), gramine, and quercetin on the microbiota in the bulk soil (Cologne agricultural soil) and investigated direct interactions of the plant secondary metabolites and ...
Physical activity and fitness for healthy ageing
(2024-02-19)
The proportion of individuals suffering from age-associated noncommunicable diseases is expected to rise rapidly in the next decades. To maintain health, well-being and socioeconomic stability in an ageing society, identifying ...
Analysis of the physiological response of perivascular adipose tissue during cold exposure
(2023-02-22)
Aortic valve disease (AVD) is common for people over 65 and its severity increases with age. Aortic aneurysm (AA) is the tenth cause of death for men above 55. Its prevalence was estimated to be up to 8.9% for men and up ...
Blutungsbedingte Nebenwirkungen der Therapie des Blepharospasmus und Hemispasmus facialis mit Botulinumneurotoxin unter antithrombotischer Medikation
(2024-03-04)
Ziel der Studie war es die Häufigkeit und Tragweite blutungsbedingter Nebenwirkungen der Behandlung des benignen essentiellen Blepharospasmus (BEB) und Hemispasmus facilais (HFS) mit Botulinumneurotoxin A (BoNT/A) unter ...
Control of pulmonary immunity by physical exercise
(2024-03-06)
Sedentary lifestyles combined with high caloric nutrition are widely known to severely contribute to the rise of metabolic diseases like diabetes, atherosclerosis, or obesity in recent years. While endurance training has ......
Immune modifying effect of drug free PLGA nanoparticles on the course of experimental autoimmune neuritis (EAN)
(2024-03-15)
Experimental autoimmune neuritis (EAN) animal model mimics the human Guillain-Barre syndrome (GBS), an autoimmune disease of demyelination and inflammation of peripheral nerves. Despite advancement in clinical management ...
Converting the elusive G protein-coupled adenosine A3 receptor into a highly-stable, well-characterized receptor model for structural studies
(2023-03-06)
The G protein-coupled adenosine A3 receptor (A3AR) is widely expressed in the human body, with the highest expression levels found in lung and liver. The receptor is involved in a number of pathological processes, e.g., ...