Faculties of University Bonn: Search
Now showing items 51-60 of 84
Investigating 5-HT2A receptors - Development of a fluorescent 5HT2A receptor agonist and elucidation of the effects of St. John's wort extract STW3-IV, hyperforin and hyperoside on 5HT2A receptors
(2021-09-22)
Investigating 5-HT2A receptors - Development of a fluorescent 5HT2A receptor agonist and elucidation of the effects of St. John's wort extract STW3-IV, hyperforin and hyperoside on 5HT2A ...
Characterization of the hyperpolarization-activated, highly-selective proton channel HCNL1 found in the sperm of the zebrafish Danio rerio
(2021-04-29)
Zebrafish are external fertilizers and release their gametes into the surrounding water. Yet, the freshwater environment with its low osmolarity poses a challenge for the gametes. Given these unique ion conditions, it seems ......
Charakterisierung des hyperpolarisationsaktivierten, hochselektiven Protonenkanals HCNL1 im Spermium des Zebrafischs Danio rerio
Zebrafische pflanzen sich durch externe Befruchtung fort und geben ......
Charakterisierung des hyperpolarisationsaktivierten, hochselektiven Protonenkanals HCNL1 im Spermium des Zebrafischs Danio rerio
Zebrafische pflanzen sich durch externe Befruchtung fort und geben ......
Molecular Mechanisms of NLRP3 Inflammasome Activation: Involvement of the Leucine-Rich Repeat Domain and Charcot-Leyden Crystals
(2021-07-29)
Chronic inflammation is a major driver of several non-communicable diseases. The cytosolic pattern recognition receptor NLRP3 is involved in the development of many of these diseases, as its activation in innate immune ...
Characterization of a novel multiprotein complex downstream of the cytosolic nucleic acid sensors cGAS and RIG-I
(2021-08-30)
Detection of viral nucleic acids by specialized PRRs of the innate immune system triggers the expression of type I IFNs, a hallmark of antiviral defense. In vertebrates, the cGAS-STING pathway and the RLR-MAVS pathway have ......
Immunostimulation of Microglia by ASC Specks and ASC Specks Amyloid β Composites
(2021-10-26)
Die Alzheimer-Krankheit stellt die weltweit häufigste Form der Demenz dar. Die genauen Mechanismen, welche zu ihrer Entstehung führen, sind bis heute nicht vollständig verstanden. Eine wichtige Rolle spielt die Aktivierung ......
Immunostimulation of Microglia by ASC Specks and ASC Specks Amyloid β Composites
Alzheimer’s Disease is the world’s most common cause of dementia. The exact mechanisms causing neurodegeneration ......
Immunostimulation of Microglia by ASC Specks and ASC Specks Amyloid β Composites
Alzheimer’s Disease is the world’s most common cause of dementia. The exact mechanisms causing neurodegeneration ......
Contributions towards a better understanding of millipede phylogenetics and sawfly genomics
(2021-03-11)
A loss of biodiversity on a scale and rate comparable to the great extinction events, as a result of anthropogenic activity, has been documented for plants, animals, and micro-organisms. In order to foster a sustainable ...
Analyse der Thermostabilität mitochondrialer Proteine anhand der Protein-Disaggregation durch Hsp78 in Bäckerhefe
(2021-02-11)
Alle Organismen zeichnen sich durch spezifische auf ihre Lebensbedingungen angepasste Charakteristika aus. Hefen, darunter auch die Bäckerhefe Saccharomyces cerevisiae, besitzt eine Vielzahl an spezialisierten Proteinen, ...
Neuronal and Circuit Architecture Underlying Feeding Behavior in Drosophila
(2021-06-28)
Feeding is elemental for survival and one of the most common activities of animals. Little is known about the organization of neuronal circuits controlling feeding behavior in the cen-tral nervous system. This study maps, ...
Etablierung und Optimierung eines Produktionssystems zur Synthese des alternativen Süßstoffs 5-Ketofruktose in Gluconobacter-Stämmen
(2021-05-21)
Übergewicht, Adipositas und Diabetes sind in der heutigen Gesellschaft längst keine seltenen Krankheiten mehr. In den letzten Jahrzehnten hat die Prävalenz dieser Erkrankungen enorm zugenommen und kann mit einer zuckerreichen ......
Hippocampal network and inhibitory neuron dysfunction in age and disease
(2021-10-25)
Aging and Alzheimer’s disease (AD) are two highly intertwined pathological processes. Indeed, one of the highest risk factors for developing AD is age. Mechanistically, it has been suggested that remodeling of inhibitory ......