Fakultäten der Universität Bonn: Suche
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Targeting aberrant dendritic integration to treat cognitive comorbidities of epilepsy
(2022-07-07)
Memory deficits are one of the most debilitating and common symptoms of temporal lobe epilepsy. However, so far, little is known about mechanisms underlying cognitive deficits and how pharmacologically target them. In most ...
RIG-I agonists as effective anti-viral prophylaxis and treatment in a mouse model of severe SARS-CoV-2 infection
(2022-07-08)
The recent outbreak of the COVID-19 pandemic highlights the need for novel prophylactic and therapeutic countermeasures against newly emerging viruses. Innate immune receptor agonists are considered to be a promising new ...
Mass Spectrometric Profiling of Lysosomal Protein Interactions, Structures, and Half-lives via Cross-Linking and Pulse Stable Isotope Labeling
(2022-07-08)
In mammalian cells, the lysosome is the central organelle for the degradation of macromolecules and recycling of their building blocks. Mutations in almost every known lysosomal hydrolase lead to a group of rare but ...
Neural Network Growth, Structure and Dynamics
(2022-07-13)
The evolutionary emergence of the nervous system provided individual organisms with a substrate for the development of complex behaviors and fast adaptations to dynamic environments. One of the main ways a nervous system ...
Targeting the Microbiome by NLRP6 Deletion and the Development of Murine Alzheimer’s Disease
(2022-07-11)
Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative brain
disorder. The progression of AD is characterized by the deposition of amyloid-β
peptides and hyperphosphorylated Tau proteins, causing loss ...
Generation of an in vitro embryo model based on cellular reprogramming paradigms in embryonic stem cells
(2022-06-30)
This research project focuses on the generation and characterization of a stem cell-based organoid model system, that can model early murine embryonic development in vitro and ex utero. Such embryo-like cell culture models ......
Wax Ester Synthases/Acyl-CoA:Diacylglycerol Acyltransferases (WS/DGATs) from Arabidopsis thaliana
(2022-06-22)
Wax esters occur in the surface wax of plants and are involved amongst others in the plant’s response to drought. In Arabidopsis thaliana, a family of 11 genes are annotated as bifunctional wax ester synthases/acyl-CoA ......
Studien zur Total- und Biosynthese von PR Toxin
(2020-03-06)
Diese Arbeit beschäftigt sich mit dem Pilzgift PR Toxin, welches aus Penicillium roqueforti isoliert werden kann. Es wurden einerseits drei Ansätze für eine Totalsynthese entwickelt und andererseits grundlegende Arbeiten ...
Soil microaggregates as habitat for microorganisms
(2022-07-27)
Aggregation of soil particles is one of the most characteristic features of terrestrial soils and crucial for their functionality. Despite the high relevance of soil aggregates, only little is known about their genesis and ...
A light-dependent aptamer-photoreceptor system enables spatiotemporal control of RNA biochemistry
(2022-07-29)
Light plays an important role in all kingdoms of life and regulates processes such as plant growth, flowering or vision in complex life forms. The growing field of optogenetics harnesses those properties by combining them ...