Fakultäten der Universität Bonn: Suche
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Validation, determinants and impact of medication use
(2024-04-02)
In recent decades, global medication consumption has increased substantially due to an aging population and more emphasis on preventative treatment. As medication use increases, concerns naturally arise regarding the ...
Invasion biology of amphibians and reptiles: From observations to predictive spatial models
(2024-04-04)
(noch nicht zugänglich / not yet accessible)
Molecular Characterization of Quality Control Factors at the Protein Entry Gate of Mitochondria
(2024-04-04)
(noch nicht zugänglich / not yet accessible)
The DEAH helicase DHX36 and its role in G-quadruplex-dependent processes
(2020-10-12)
DHX36 is a member of the DExD/H box helicasefamily, which comprises a large number of proteinsinvolved in various cellular functions. Recently, thefunction of DHX36 in the regulation of G-quadruplexes(G4s) was demonstrated. ......
Detecting G4 unwinding
(2022-04-18)
DNA can, in addition to the B-DNA conformation, fold into a variety of additional conformations. Among them are G-quadruplex structures that have gained a lot of attention in recent years. G-quadruplex structures (G4s) are ...
Cell Cycle Regulation of G-Quadruplex DNA Structures at Telomeres
(2012-05-01)
DNA and RNA regions containing tracts of guanines can form very stable secondary structures called G-quadruplex (G4). Genomic sequences with the potential to form G4 (G4-motifs) are abundant across species. In all analyzed ...
Establishing blood-based classifiers for decentralized and privacy-preserving disease prediction
(2024-04-08)
Big data is increasingly being generated across all sectors of medicine and high-dimensional omics data have been shown to be a powerful data space for AI applications that can assist in primary and differential diagnostics, ...
Identification of alpha-synuclein and ataxin-3 expression modifying compounds
(2024-02-16)
(noch nicht zugänglich / not yet accessible)
Cytokine Production of CD56bright Natural Killer Cells From Human Immunodeficiency Virus–Infected Individuals Under Effective Antiretroviral Therapy
(2022-09-01)
Human immunodeficiency virus (HIV) infection is associated with impaired natural killer (NK) cell activity, which is only incompletely restored under antiretroviral therapy. Analyzing the bioenergetics profiles of oxygen ...
Obesity impairs virus-specific memory CD8+ T cell signalling and function
(2024-04-11)
The main function of the immune system is to protect the host against invading pathogens. Immunological memory is formed after a primary infection and serves to provide protection in a fast and vigorous manner upon secondary ...