Fakultäten der Universität Bonn: Suche
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Influence of disulfide-bonds on structural and functional properties of peptides and proteins - Case studies on FXIIIa inhibitor tridegin and µ-conotoxin PIIIA
(2021-05-28)
Disulfide-bonded peptides have been studied for many decades serving as tools to investigate various biochemical pathways as well as lead structures for drug development for numerous diseases. Among these, the most fatal ...
Mapping the immune landscape in the alveolar space reveals alterations of multiple macrophage states in chronic obstructive pulmonary disease
(2021-03-26)
Chronic obstructive pulmonary disease (COPD) is ranked among the three leading causes of death worldwide and hence constitutes a significant burden, both medically and financially. The disease is characterized by a poorly ...
Investigation of SECISBP2 mutations and potential viral SECIS element recruitment
(2021-07-15)
The 21st amino acid selenocysteine (Sec) is encoded by the UGA codon. In order to recode the canonical stop codon additional factors are needed in mammals including the selenocysteine-insertion-sequence (SECIS) ......
Neuroinvasion and cerebral ischemia as possible sources for α-synuclein prions in Parkinson’s disease
(2021-07-13)
In synucleinopathies such as Parkinson’s disease misfolding of α-synuclein, normally a cellular and soluble protein, leads to the accumulation of insoluble protein aggregates and to central nervous system disease (CNS). ...
Geriatrische Medikationsanalyse für Pflegeheimbewohner durch öffentliche Apotheken
(2020-05-18)
Pflegeheimbewohner sind häufig von Polymedikation und damit einhergehenden arzneimittelbezogenen Problemen (ABP) betroffen. Medikationsanalysen können die Angemessenheit der Medikation bei Älteren verbessern. Mit der ...
Functional markers for cerebral norepinephrine deficiency in Alzheimer's disease
(2021-02-17)
Pathological alterations of the locus coeruleus (LC)-norepinephrine (NE) system occur early in the course of Alzheimer’s disease (AD), and manifest in poor attention and distractibility. Cortical NE is released from the ...
Hormone und Demenz: Eine pharmakoepidemiologische Analyse
(2020-12-16)
Die Untersuchung potentieller Risikofaktoren für eine Demenzerkrankung ist ein wichtiger Bestandteil der primären Prävention. Die weite Verbreitung der Einnahme von Hormonen und hormonbeeinflussenden Medikamenten für ...
Multiprofessionelles Medikationsmanagement für ambulante Patienten mit intravenös applizierter Tumortherapie
(2020-11-02)
Bei ambulanten Tumorpatienten ist die Arzneimitteltherapiesicherheit eine stetige Herausforderung. Ein multiprofessionelles Medikationsmanagement kann zu einer angemessenen Arzneimitteltherapie und einem fehlerfreien ...
The role of Sphingosine-1-phosphate receptors in adipocytes and adipose tissues
(2021-01-19)
Obesity is a worldwide health issue with increasing numbers of patients every year. Moreover, the prevalence of obesity gives rise to related cardiovascular diseases and various other comorbidities influencing quality of ...
Loss of Inhibitory CD33 Signaling Results in Increased Microglial Activation
(2021-06-23)
CD33 is expressed on immune cells of myeloid origin, such as macrophages and microglia. Upon activation, CD33 recruits and activates protein tyrosine phosphatases, which results in attenuation of the activatory signaling ...