Fakultäten der Universität Bonn: Suche
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Die Effekte des Multikinase-Inhibitors Regorafenib auf die zirrhotische und nicht-zirrhotische portale Hypertension im Rattenmodell
(2020-07-10)
Einleitung: Chronische Lebererkrankungen führen zu einer portalen Hypertension mit schwerwiegenden Komplikationen für Patienten. Eine pathologisch gesteigerte, extrahepatische Angiogenese ist ursächlich an der Entstehung ...
Mapping the immune landscape in the alveolar space reveals alterations of multiple macrophage states in chronic obstructive pulmonary disease
(2021-03-26)
Chronic obstructive pulmonary disease (COPD) is ranked among the three leading causes of death worldwide and hence constitutes a significant burden, both medically and financially. The disease is characterized by a poorly ...
Statistical methods and epidemiology of chronic conditions in the field of general practice and family medicine
(2020-06-23)
The field of general practice and family medicine is diverse and has to deal with several complex health problems. Essential characteristics of general practitioner (GP) services cover among others a comprehensive, ...
Untersuchungen zu pharmakogenetischen Grundlagen der Hyponatriämie durch Carbamazepin, Oxcarbazepin und Eslicarbazepin bei Menschen mit Epilepsie
(2020-07-10)
Die Epilepsie ist eine häufig in der Bevölkerung auftretende, chronische neurologische Erkrankung, welche sich bei 61 von 100.000 Menschen pro Jahr neu manifestiert.
Carbamazepin, Oxcarbazepin und Eslicarbazepin werden ...
Structural aspects of the plasmalemmal Amyloid Precursor Protein cluster
(2021-11-12)
Alzheimer’s Disease (AD) is a major socio-economic threat to health care systems and society in general. Involvement of the amyloid-beta peptide (Aβ) and its parent, the amyloid precursor protein (APP), in AD seemed obvious ...
Die Expression der Nervenwachstumsfaktor-Rezeptoren TrkA und p75 auf einem erhöhten Anteil dendritischer Zellen und peripheren Leukozyten bei Patienten mit systemischem Lupus erythematodes in Abhängigkeit von der Krankheitsaktivität
(2021-06-01)
Rheumatische Erkrankungen sind durch lokale und/oder systemische entzündliche Aktivität charakterisiert, häufig einhergehend mit Endorganschäden und Schmerzen. Eine Aktivierung des Nervensystems legt die Vermutung nahe, ...
Forward programmed neurons as a tool for human neuronal network analysis and disease modeling
(2022-02-08)
Introduction: Forward programming enables the generation of highly pure excitatory and inhibitory neurons from human pluripotent stem cells (hPSCs). This study is to establish and functionally characterize ......
Melanoma immunosurveillance by CD4+ T cells
(2021-07-05)
The immune system can recognise and control cancer cells in a process termed cancer immunosurveillance. There is increasing evidence that CD4+ T cells play an important role in melanoma immunosurveillance but ...
Memory and Neurodegeneration Across the Lifespan
(2021-10-07)
The prevention and treatment of age-related memory impairment requires the early detection of underlying pathological changes and the availability of effective risk modifying intervention. This, in turn, demands research ...
Investigation of SECISBP2 mutations and potential viral SECIS element recruitment
(2021-07-15)
The 21st amino acid selenocysteine (Sec) is encoded by the UGA codon. In order to recode the canonical stop codon additional factors are needed in mammals including the selenocysteine-insertion-sequence (SECIS) ......