Fakultäten der Universität Bonn: Suche
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Modulation der Gαi1/s-Proteinaktivität durch lineare und makrozyklische Peptide
(2021-07-08)
Die vorliegende Dissertation beschäftigt sich mit der Identifizierung und Charakterisierung von peptidischen Modulatoren für die Gαi/s-Proteinaktivität. Die Ga-Untereinheit heterotrimerer G-Proteine ist eine bedeutende ...
Nucleic acid sensing in CD4 T cells during HIV-1 and other viral infections
(2021-10-15)
Viruses are small intracellular parasites and use the host cell’s biosynthesis machinery to replicate and spread. Therefore, viral particles incorporate structures that are similar to the ones that naturally occur within ...
OptoRiboGenetics: Post-transcriptional control of gene expression by light
(2021-08-26)
Gene expression is tightly regulated in mammalian cells at the post transcriptional level and its precise manipulation has proven to be valuable for protein overexpression and gene therapy. Implementation of light-responsive ......
OptoRiboGenetics - Posttranskriptionelle Kontrolle der Genexpression mit Licht
Die Genexpression von Säugetierzellen wird maßgeblich auf post-transkriptioneller Ebene reguliert und das Eingreifen auf ......
OptoRiboGenetics - Posttranskriptionelle Kontrolle der Genexpression mit Licht
Die Genexpression von Säugetierzellen wird maßgeblich auf post-transkriptioneller Ebene reguliert und das Eingreifen auf ......
Investigation of Quinazoline Derivatives as Inhibitors of Breast Cancer Resistance Protein (BCRP/ABCG2)
(2018-03-12)
The treatment of cancer with chemotherapeutic drugs is strongly limited by intrinsic or aquired resistance of the cancer cells. This is the main reason of a failure of the therapy. The cellular resistance mostly originates ...
Development and Application of Efficient Methods for the Computation of Electronic Spectra of Large Systems
(2018-04-13)
In this thesis, an efficient procedure to compute electronic excitation spectra of molecular systems is presented, focusing particularly on the computation of electronic circular dichroism (ECD) spectra. ECD spectroscopy ...
Mechanistic Investigation of a HAuCl4 catalyzed oxidative C-C coupling reaction and Synthesis of new supramolecular Silver(I) and Gold(I) NHC compounds: or handling of a Mass Spectrometric Challenge and catching Counterions on Supramolecular Playgrounds
(2021-04-22)
Reaction monitoring by electrospray (ESI) mass spectrometry is a valuable technique to investigate reaction mechanisms. It allows a glimpse into the reacting solution and the characterization of transient intermediates ......
EPR distance measurements using triaryl methyl radicals and EPR investigation of electron transfer processes in organic radicals
(2018-04-17)
EPR is a valuable tool for the investigation of biological structures. Most EPR-based distance measurements rely on the site directed spin labeling of the investigated biomolecule, since most biomolecular structures do not ...
The role of guanine nucleotide exchange factors (GEFs) in EGF-receptor signalling: Screening for a small molecule inhibitor of the Rin1-mediated Rab5 activation
(2018-06-04)
The small GTPase Rab5 is a key regulator of early endosomal trafficking. It functions as a molecular switch that can be activated by guanine nucleotide exchange factors (GEFs) and inactivated via hydrolysis of GTP with the ...
Hochauflösende Protonen-Transfer-Reaktions-Massenspektrometrie zur Bestimmung des photochemischen Abbaus von grünen Blattduftstoffen
(2018-04-27)
Die globalen Emissionen von biogenen flüchtigen organischen Verbindungen (1089 Tg/y, Guenther et al. [2012]) übersteigen die globalen Emissionen anthropogen Ursprungs (110 Tg/y, Piccot et al. [1992]) um beinahe ......
Ternäre Zintl-Phasen (Erd)Alkalimetall-Triel-Pentel und deren partielle Oxidation zu Pentelidgallaten
(2018-06-04)
Im Rahmen dieser Arbeit konnte ein Großteil der bisher noch fehlenden Vertreter der ternären Zintl-Phasen der Zusammensetzung Alkalimetall-Triel-Bismut dargestellt werden. Während die große Mehrzahl dieser Zintl-Phasen in ...