Faculties of University Bonn: Search
Now showing items 1-10 of 24
Influence of High-Pressure Compaction of Binary Mixtures on Solubility, Dissolution and Wettability of Borderline Poorly Soluble Drugs Employing Standard Excipients
(2021-12-14)
Many of new drug candidates are impaired by low aqueous solubility and slow dissolution rates, which may hinder their pharmacological response. Therefore, there is an increasing need to investigate and implement new ...
Influence of disulfide-bonds on structural and functional properties of peptides and proteins - Case studies on FXIIIa inhibitor tridegin and µ-conotoxin PIIIA
(2021-05-28)
Disulfide-bonded peptides have been studied for many decades serving as tools to investigate various biochemical pathways as well as lead structures for drug development for numerous diseases. Among these, the most fatal ...
Multiprofessionelles Medikationsmanagement für ambulante Patienten mit intravenös applizierter Tumortherapie
(2020-11-02)
Bei ambulanten Tumorpatienten ist die Arzneimitteltherapiesicherheit eine stetige Herausforderung. Ein multiprofessionelles Medikationsmanagement kann zu einer angemessenen Arzneimitteltherapie und einem fehlerfreien ...
Role of Endothelin-1 in the Brown Adipose Tissue
(2021-06-22)
ET-1 was shown to inhibit adipogenesis in murine mesenchymal stem cells derived from new-born brown adipose tissue in vitro and antagonism of Endothelin-1 (ET-1) signaling at the respective level of the Endothelin-1 receptor ...
Inducing immunity to liver stage malaria through endogenous tissue resident memory cells
(2020-12-16)
Tissue-resident memory CD8 T (TRM) cells provide effective tissue surveillance and can respond rapidly to infection due to their strategic location. Within the liver, TRM cells can induce effective protection against ...
The role of YAP signaling in thermogenic adiposetissues
(2021-01-02)
One of major metabolic organs, brown adipose tissue (BAT), is responsible for energy expenditure through uncoupling protein 1 (UCP1) mediated non-shivering thermogenesis, which has been considered a promising pharmacological ...
The role of Sphingosine-1-phosphate receptors in adipocytes and adipose tissues
(2021-01-19)
Obesity is a worldwide health issue with increasing numbers of patients every year. Moreover, the prevalence of obesity gives rise to related cardiovascular diseases and various other comorbidities influencing quality of ...
Studien zur oxidativen Faltung des Faktor-XIIIa-Inhibitors Tridegin
(2020-11-16)
Diese Dissertation beschäftigt sich mit der umfassenden Charakterisierung des Naturstoffs Tridegin. Dieses cysteinreiche, 66 Aminosäuren lange Peptid ist ein spezifischer Inhibitor des letzten Schrittes der Blutgerinnungskaskade, ......
Studies on the oxidative folding of factor XIIIa inhibitor tridegin
This PhD thesis deals with the detailed characterization of the natural compound tridegin. This cysteine-rich 66mer peptide ......
Studies on the oxidative folding of factor XIIIa inhibitor tridegin
This PhD thesis deals with the detailed characterization of the natural compound tridegin. This cysteine-rich 66mer peptide ......
Totalsynthesen neuartiger Leupylogs: vereinfachte Strukturanaloga der Leupyrrine
(2020-06-03)
Die vorliegende Dissertation behandelt die totalsynthetische Darstellung von neuartigen Strukturanaloga der Leupyrrine. Diese Stoffklasse myxobakterieller Sekundärmetabolite zeichnet sich durch die Kombination einzigartiger ......
Total Synthesis of novel Leupylogs – simplified Structural Analogues of Leupyrrins
This submitted thesis deals with the development of the total synthesis of novel Leupylogs, structural leupyrrin ......
Total Synthesis of novel Leupylogs – simplified Structural Analogues of Leupyrrins
This submitted thesis deals with the development of the total synthesis of novel Leupylogs, structural leupyrrin ......
Population pharmacokinetic modeling to understand antineoplastic treatment
(2020-06-29)
Introduction: The pronounced variability in pharmacokinetics of antineoplastic drugs caused by known and unknown sources translates into variability in therapeutic outcome. This is a major concern for these ...