Faculties of University Bonn: Fakultäten der Universität Bonn: Recent submissions
Now showing items 541-560 of 9483
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Effects of microRNA overexpression on cone photoreceptor survival and structure in health and disease
(2025-01-21)Inherited retinal diseases (IRDs) and age-related macular degeneration (AMD) are characterized by the loss of photoreceptors, the sensory neurons in the retina, leading to severe vision loss. Retinitis pigmentosa (RP), the ... -
Vascularization of human iPSC-derived 3D retinal organoids and its impact on ganglion cell survival
(2025-01-21)ROs have emerged as a transformative platform for studying retinal cell development and modeling retinal diseases. These 3D structures, derived from SCs, replicate the architecture and function of the retina, offering ... -
Investigation of Layer-specific Responses to Colon Anastomosis and Disturbed Healing Pathways in Non-steroidal Anti-inflammatory Drug (NSAID)-induced Colon Anastomotic Leakage
(2025-01-21)<strong>Introduction: </strong> Colon anastomotic leakage (CAL) is a postoperative complication originating from disturbed colon anastomotic healing (CAH). Wound healing involves several well-coordinated stages, which have ... -
Hyperon Spectrum in a dynamical coupled-channel approach
(2025-01-20)In this study, we investigate the $bar{K}N$ reactions using a coupled-channels approach, covering the range of center of mass energies from the $bar{K}N$ threshold up to 2 GeV. We develop a dynamical coupled-channel model ... -
Evidence for tt̄tt̄ production in the multilepton final state in proton–proton collisions at √s = 13 TeV with the ATLAS detector at the LHC
(2025-01-20)The first evidence for simultaneous production of four top quarks is presented. The measurement is conducted by selecting events having two same-charge leptons or at least three leptons and by analysing 139 fb<sup>-1</sup> ... -
Robotic Vision for Precision Intervention in Horticulture
(2025-01-20)Striving towards optimal sustainable agriculture systems to address the world’s growing demand for food, precision agriculture has emerged as a key strategy. In recent years robotic systems have gained remarkable capabilities ... -
Digital Platforms and Social Networks: Three Essays in Microeconomic Theory
(2025-01-20)This dissertation consists of three self-contained chapters that employ theoretical methods to shed light on the effects of personalization algorithms in social media platforms, the role of rating systems on streaming ... -
Untersuchungen zur Darstellung und Reaktivität von σ3λ3-Oxaphosphiranen
(2025-01-17)Im Rahmen der vorliegenden Arbeit wurde die Freisetzung von σ<sup>3</sup>λ<sup>3</sup>-Oxaphosphiranliganden aus <em>P</em>-CPh<sub>3</sub>-substituierten Oxaphosphiranmetallkomplexen untersucht. Des Weiteren wurde die ... -
Modelling Secondary Circulation in Convective Boundary Layer Using Large Eddy Simulation
(2025-01-17)Mesoscale secondary circulations, which frequently arise over heterogeneous land surfaces, profoundly influence atmospheric structure and characteristics. Its structure is primarily shaped by the combined effects of wind ... -
TCAD Simulations and Test Beam Characterization of MAPS for Future Lepton Colliders
(2025-01-17)Monolithic active pixel sensors (MAPS) produced in a 65 nm CMOS imaging technology are being investigated for applications in particle physics. The MAPS design has a small collection electrode with an input capacitance of ... -
Investigating the Biosynthesis of G Protein Inhibitor FR900359
(2025-01-17)FR900359 (FR) is a potent and selective inhibitor of Gq proteins, obstructing intracellular signaling of numerous G protein-coupled receptors (GPCRs). This makes it a promising pharmacological tool for investigating ... -
Study of B → π ℓ ν and B → ρ ℓ ν decays and extraction of |Vub| at Belle II
(2025-01-16)This thesis presents a measurement of the Cabibbo-Kobayashi-Maskawa (CKM) matrix element magnitude |<em>V<sub>ub</sub></em>| from a simultaneous study of the semileptonic decays <em>B<sup>0</sup> → π<sup>-</sup> ℓ<sup>+</sup> ... -
Root trait response to drought, recovery, and P deficiency of upland rice
(2025-01-16)Phosphorus deficit and intermittent drought can cause high-yield reductions in rice (Oryza sativa L.) production. Large differences in tolerance of low P availability and drought resilience were found in the upland rice, ... -
Blutplasmabestimmung von Brivaracetam, Lacosamid und Perampanel: Behandlungsrelevanz für Epilepsiepatienten
(2025-01-16)Anfallssuppressive Medikamente stellen die Basistherapie von Epilepsiepatienten dar. Ob die Bestimmung der Wirkstoffspiegel dazu beiträgt, die klinische Wirksamkeit zu verbessern und Nebenwirkungen zu vermeiden, ist bisher ... -
Hämodynamische und renale Wirkung des Urotensin II-Rezeptor-Antagonisten Palosuran bei Ratten mit sekundärer biliärer Zirrhose
(2025-01-16)Die führende Rolle in der Entstehung des portalen Hypertonus bei Leberzirrhose nimmt die splanchnische Vasodilatation ein. Trotz der kompensatorischen Aktivierung vasoaktiver Systeme wie zum Beispiel des Renin-Angiotensi ... -
From Comments to Cognition: How online comments on social media influence personal opinion
(2025-01-16)Social media has become central in our daily life, serving both as a mean of interpersonal connection and as a primary source of news consumption. This doctoral dissertation investigates the behavioral and neuroimaging ... -
DNA-Methylierung der FGF-Rezeptoren hinsichtlich der mRNA-Expression, Amplifikation und Sensitivität für Inhibitoren in Plattenepithelkarzinomen der Lunge
(2025-01-14)Während zielgerichtete Therapien beim Adenokarzinom der Lunge inzwischen erfolgreich routinemäßig angewendet werden, sind die klinischen Ergebnisse beim LUSC ernüchternd. Ein Grund hierfür könnte eine ungenügende ... -
Analyse der hämodynamischen Reaktion auf die hypertherme intraoperative Chemoperfusion: Eine deskriptive Studie
(2025-01-14)Die Erhaltung des physiologischen Grundzustandes eines operierten Menschens während einer Operation ist die Hauptaufgabe des Anästhesieteams. Ein wichtiges Element ist dabei die Hämodynamik. Diese muss während eines ... -
Importance of root-soil contact conditions for the microbiota in the soil-rhizosphere-plant continuum
(2025-01-14)The contact zone between a root and the surrounding soil mediates processes such as nutrient and water uptake and the interaction with microorganisms. Despite the importance of the contact zone, there is a lack of understanding ... -
Entwicklung eines neuen Cluster-Finders für das Crystal-Barrel-Kalorimeter
(2025-01-10)Mit der experimentellen Untersuchung des Anregungsspektrums von Hadronen können Vorhersagen von Quarkmodellen sowie von Gitter-QCD-Rechnungen getestet und damit ein tieferes Verständnis der zugrundeliegenden starken ...
