The Faculty of Medicine: Search
Now showing items 41-50 of 84
Functions of the DEAH-box helicase DHX36 in type I interferon signaling
(2023-01-06)
The induction of type I interferons (IFN) is a hallmark of foreign nucleic acids immune sensing by the innate immune system. Based on the universal molecular structure of DNA and RNA throughout all kingdoms of life, the ...
PML and its degradation by arsenic trioxide in interferon-mediated neuro-inflammation
(2023-02-06)
Activation of interferon type-I (IFN-I) production and downstream signaling pathways mediate the tissue response to pathogens such as viruses, but its aberrant activation has been suggested to contribute to the aging process ...
Pharmacologic intervention in macrophage metabolism: Mitochondrial pyruvate carrier inhibition by Mitoglitazone modulates inflammation
(2023-08-09)
Upon Toll-like receptor (TLR) activation, macrophages rapidly change their transcriptional- and translational network and rewire their metabolism. Mitochondrial pyruvate import via the mitochondrial pyruvate carrier (MPC) ...
Legionnaires' Disease - the impact of cigarette smoke and functional lung recovery
(2023-02-14)
Legionnaires’ Disease is a severe type of pneumonia most commonly caused by the bacterial species Legionella pneumophila and Legionella longbeachae. Epidemiological studies show that cigarette smoke is a major risk factor ......
Primary cilia and their effects on immune cell functions and metabolism: a model
(2022-05)
Primary cilia are hair-like protrusions of the plasma membrane that function as cellular antennae and are present on most cells in the human body. Primary cilia dysfunction leads to severe diseases, commonly termed ...
Characterization of the zinc-sensitive metal-regulatory transcription factor 1 in hippocampal epileptic network formation using an animal model of Temporal Lobe Epilepsy
(2023-10-02)
Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy. It usually occurs after a transient brain insult, including status epilepticus (SE), which triggers a latent period of epileptogenesis prior to the ......
A basal forebrain to midbrain circuit drives exploratory locomotion
(2023-10-26)
Locomotion is a fundamental behavior that comprises different specialized neuronal networks. In the basal forebrain, the glutamatergic neurons of the medial septum and diagonal band of Broca (MSDBglu) can initiate ......
Development of a CRISPR/Cas9 based RiboTag strategy to identify regulators of melanoma immune interaction
(2023-11-09)
The development of immunotherapy approaches has revolutionised the field of melanoma treatment by prolonging the survival of patients. Nevertheless, a significant proportion of patients either do not respond to immunotherapy ...
Role of the chemokines CCL17 and CCL22 in bacterial infection and IL-33-induced immune responses
(2023-11-24)
The chemokines CCL17 and CCL22 are primarily expressed by dendritic cells (DC) and macrophages. Both chemokines share the receptor CCR4, which is expressed on DC and macrophages as well as on a variety of different T cell ......
Investigating the ability of RIG-I agonists to provide protection in mouse and ferret models of respiratory virus infection
(2022-05-17)
Respiratory infections caused by influenza A virus (IAV) or respiratory syncytial virus (RSV) lead to substantial morbidity and mortality. Treatment options are limited and there is urgent need for the development of ......