Medizinische Fakultät: Suche
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Search for exosomes in NG2-glial cells
(2022-02-17)
NG2-glial cells is an abundant and widely distributed subtype of glia, featuring properties not typically associated with mature glial cells, such as the ability to receive synaptic input from neurons, or adult proliferation. ...
Establishment of an inducible human pluripotent stem cell-based 3D model of Alzheimer's disease
(2020-11-16)
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease in the aged population. The vast majority of cases are sporadic, however, various mutations may cause early-onset, familial AD (FAD) variants. AD is ...
Low molecular weight polysialic acid prevents lipopolysaccharide-induced inflammatory dopaminergic neurodegeneration in humanized SIGLEC11 transgenic mice
(2021-07-13)
Parkinson’s disease is one of the most common neurodegenerative diseases in the elderly population, with a pathophysiology linked to neuroinflammation, complement activation and oxidative damage. Soluble polysialic acid ...
Impact of chronic liver inflammation on adaptive immune responses to viral infection
(2020-03-11)
A common complication in patients suffering from chronic liver inflammation and fibrosis is the enhanced susceptibility to viral infections and weak responses to vaccination, which are associated with significant co-morbidities. ...
Neuroinflammation, microglia and the cell biology of Alzheimer's Disease
(2020-04-08)
The pathology of Alzheimer’s disease (AD) is characterised by progressive accumulation of misfolded proteins, which form senile plaques and neurofibrillary tangles, and chronic inflammation in the brain associated with ...
Immune defense mechanisms against Legionella longbeachae
(2020-01-30)
The pulmonary epithelial barrier is the first line of defense against pathogens invading the lungs. If those are able to overcome this first barrier, myeloid cells of the innate immune system are instrumental for the ......
Investigation of novel pathways causing autoinflammatory disease
(2022-05-17)
Autoinflammatory diseases (AIDs) are rare pathologies caused by mutations in genes associated with innate immune pathways. Investigating the underlying molecular defects contributes to identification of targeted treatment ......
The role of innate lymphoid cells in liver disease: Identification of a hepatic IL-13-producing ILC3-like population potentially involved in liver fibrosis
(2022-05-23)
Innate lymphoid cells (ILCs) are a family of innate immune cells that mirror the functionality of T lymphocytes but do not express rearranged antigen receptors. As tissue-resident cells, ILCs primarily reside in peripheral ...
Participation of Ste20-like kinase-deficient neurons in the abnormal circuitry of focal epileptogenic lesions
(2022-01-03)
Focal epileptogenic lesions displaying morphologically altered neurons are frequently associated with devastating and therapy-refractory epilepsies. However, it is still unsolved how dysplastic neurons contribute to the ...
Immunostimulation of Microglia by ASC Specks and ASC Specks Amyloid β Composites
(2021-10-26)
Die Alzheimer-Krankheit stellt die weltweit häufigste Form der Demenz dar. Die genauen Mechanismen, welche zu ihrer Entstehung führen, sind bis heute nicht vollständig verstanden. Eine wichtige Rolle spielt die Aktivierung ......
Immunostimulation of Microglia by ASC Specks and ASC Specks Amyloid β Composites
Alzheimer’s Disease is the world’s most common cause of dementia. The exact mechanisms causing neurodegeneration ......
Immunostimulation of Microglia by ASC Specks and ASC Specks Amyloid β Composites
Alzheimer’s Disease is the world’s most common cause of dementia. The exact mechanisms causing neurodegeneration ......