Medizinische Fakultät: Suche
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Platelets shape the immune response of primary human monocytes
(2023-01-13)
Monocytes are circulating immune cells essential to host defense, orchestrating immune responses through the secretion of immunomodulatory mediators. While exuberant monocyte-driven immune responses have life-threatening ...
The role of CH25H in adipose tissue - a new potential target in anti-obesity therapy?
(2024-06-25)
Obesity associates with comorbidities as hypertension, cardiovascular disease, metabolic syndrome and type 2 diabetes mellitus and therefore depicts an emerging health issue. On a molecular level, obesity is accompanied ......
Interplay of IKKs and IKK-related kinases in antiviral nucleic acid receptor signaling in human monocytes
(2022-06-21)
Monocytes and monocyte-derived cells are equipped with pattern recognition receptors (PRRs) that detect conserved components of pathogens and in response initiate signaling cascades that result in the production of warning ...
Heterogeneity in Kupffer cell-mediated killing of Staphylococcus aureus
(2024-07-24)
Staphylococcus aureus, an opportunistic pathogen, exhibits remarkable adeptness in evading the host's innate immune defenses to establish infections. In this context, Kupffer cells, specialized resident macrophages in the ......
Isolation and Flow Cytometry Analysis of Macrophages from White Adipose Tissue
(2023-08-29)
Macrophages are one of the prominent leukocyte populations in white adipose tissue (WAT) and play an important role during WAT homeostasis and remodeling. Macrophage function in WAT is determined by ontogeny and the local ...
Die Rolle von Fraktalkin in der Aristolochiasäure-induzierten Nephropathie
(2024-08-12)
Die Fraktalkin (CX3CL1/R1) Achse spielt eine bedeutende Rolle in der Rekrutierung von Immunzellen in verschiedenste Organe. In dieser Arbeit untersuchten wir die Rolle von CX3CR1 exprimierenden Immunzellen in der ...
Influence of antiviral RNA binding effector proteins on innate immune responses
(2024-08-06)
The efficient elimination of viruses is initiated by the recognition of the viral nucleic acid genome or replication intermediates through innate immune receptors. Several different receptors specifically detect double ......
Cytokine Production of CD56bright Natural Killer Cells From Human Immunodeficiency Virus–Infected Individuals Under Effective Antiretroviral Therapy
(2022-09-01)
Human immunodeficiency virus (HIV) infection is associated with impaired natural killer (NK) cell activity, which is only incompletely restored under antiretroviral therapy. Analyzing the bioenergetics profiles of oxygen ...
Genetic analyses on male-pattern hair loss: Exploring links with rare variants, COVID-19 and short anagen hair syndrome
(2024-09-10)
Male pattern hair loss (MPHL) is a highly heritable condition and the most common form of hair loss in men. The phenotype is characterized by progressive hair loss in the frontotemporal and vertex areas of the scalp. ...
Integrative analysis of common and rare pathogenic variants for a more comprehensive genetic risk assessment
(2024-09-11)
Throughout this thesis, we examine the complex interplay between genetic factors, namely polygenic risk scores (PRS), rare pathogenic variants, and the impact of family history on the risk of complex diseases (e.g., breast ...