Medizinische Fakultät: Suche
Anzeige der Dokumente 11-20 von 24
The cell biology of the FcRn-albumin recycling system
(2022-08-10)
Human serum albumin (HSA) is the most abundant protein in plasma and has an exceptionally long circulatory half-life of around three weeks in humans. The enhanced half-life properties of HSA result from the selective ...
Pathogenetic insights from novel mouse models for human epilepsy-associated developmental glioneuronal tumors
(2022-09-21)
Background: Developmental, biologically benign brain tumors associated with epilepsy represent a highly heterogeneous group of neoplasms and include glioneuronal and glial entities. Gangliogliomas (GGs) ......
Presenilin deficiency leads to altered protein N-glycosylation and endo-lysosomal cholesterol accumulation
(2022-11-08)
Major genetic causes of familial Alzheimer disease are mutations in genes encoding presenilin (PS) 1 and 2. PS1 and PS2 are known to constitute the catalytic subunits of the γ-secretase complex, but also for being ......
The mind's ratio: How the balance between ω-6 and ω-3 fatty acids affects the risk of late-life dementia
(2022-02-03)
Dementia health care costs are rapidly rising due to the increasing number of people with dementia worldwide that is expected to increase to 66 million by 2030 and 115 million by 2050 (Prince et al., 2013). Intensive ......
Fatty liver disrupts homeostatic functions of Kupffer cells in liver regeneration
(2022-04-22)
Obesity-associated liver disease represents a continuously increasing health concern. Besides the risk of obese individuals towards liver dysfunction, cirrhosis and hepatocellular carcinoma, an increased risk for defective ......
RIG-I agonists as effective anti-viral prophylaxis and treatment in a mouse model of severe SARS-CoV-2 infection
(2022-07-08)
The recent outbreak of the COVID-19 pandemic highlights the need for novel prophylactic and therapeutic countermeasures against newly emerging viruses. Innate immune receptor agonists are considered to be a promising new ...
Targeting the Microbiome by NLRP6 Deletion and the Development of Murine Alzheimer’s Disease
(2022-07-11)
Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative brain
disorder. The progression of AD is characterized by the deposition of amyloid-β
peptides and hyperphosphorylated Tau proteins, causing loss ...
Primary cilia and their effects on immune cell functions and metabolism: a model
(2022-05)
Primary cilia are hair-like protrusions of the plasma membrane that function as cellular antennae and are present on most cells in the human body. Primary cilia dysfunction leads to severe diseases, commonly termed ...
Investigating the ability of RIG-I agonists to provide protection in mouse and ferret models of respiratory virus infection
(2022-05-17)
Respiratory infections caused by influenza A virus (IAV) or respiratory syncytial virus (RSV) lead to substantial morbidity and mortality. Treatment options are limited and there is urgent need for the development of ......
Chronic Helminth Infection Ameliorates Colitis via ***** regeneration program
(2022-03-07)
(noch nicht zugänglich / not yet accessible)