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Unravelling the role of RIM proteins in synaptic transmission: RIM1α tunes Ca2+ channel subtype contribution to neurotransmitter release
(2019-04-12)
Synaptic transmission is extremely fast and tightly regulated due to the rapid and spatially restricted Ca2+ signal at the presynaptic active zone (AZ). At the AZ, voltage-gated Ca2+ channels (VGCC) ...
Elucidating cyclic AMP signaling in subcellular domains with optogenetic tools and fluorescent biosensors
(2019-11-14)
The second messenger 3´, 5´-cyclic nucleoside adenosine monophosphate (cAMP) plays a key role in signal transduction across prokaryotes and eukaryotes. Cyclic AMP signaling is compartmentalized into microdomains to fulfil ...