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Epigenetic regulation of lentiviral and retroviral vectors in murine embryonic stem (ES) cells and genetic modification of ES cells with lentiviral vectors for application in regenerative medicine
(2013-06-13)
Embryonic stem cells are characterized by their self-renewal capability and pluripotency. They represent an unlimited cell source for regenerative medicine. In order to genetically modify ES cells for gene therapy, ......
Many facets of CPEB proteins in neurons and beyond: expression, mRNA recognition and phosphorylation
(2013-06-10)
CPEBs are a family of evolutionary conserved auxiliary translational factors. They bind to CPEs in the 3’UTR of target mRNA and, by interacting with other members of the translational machinery, promote or decrease gene ......
Großwetterlagen und das raumzeitliche Muster des Jahrringwachstums in Mitteleuropa: ein neuer methodischer Analyseansatz
(2013-07-08)
Für das Verständnis des Klimasystems ist es unerlässlich, lange Zeiträume zu betrachten. Dieses Vorgehen ermöglicht es, die Prozesse und Rückkopplungen im Klimasystem zu beschreiben, auf ihre Periodizität hin zu untersuchen ...
AFM-Untersuchungen auf Elektrodenoberflächen
(2013-07-10)
In der vorliegenden Arbeit wurde eine Analyse der Reibung an Elektroden in Elektrolyten durchgeführt. Dabei wurde das Verhalten der reibenden Körper bei unterschiedlicher Normalkraft und Krümmung (Rauhigkeit) des Kontaktes ...
Antisymmetrisation in a Jacobi coordinate based no-core shell model approach
(2013-06-13)
The theory of the strong interaction, Quantum Chromodynamics (QCD), provides the generally accepted description of strongly interacting processes. Due to the confinement of the fundamental degrees of freedom of QCD, the ...
Die pflanzlichen Biopolyester Kutin und Suberin: Chemische Zusammensetzung und Biosynthese
(2013-05-15)
Ziel meiner Arbeit war es, anhand ausgewählter Lipidstoffwechsel-Mutanten Rückschlüsse auf die Beteiligung der untersuchten Gene an der Polyesterbildung von Kutin und Suberin zu ziehen. Untersucht wurden die Polyesterzus ......
Multivariate methods and the search for single top-quark production in association with a W boson in ATLAS
(2013-05-28)
This thesis describes three machine learning algorithms that can be used for physics analyses. The first is a density estimator that was derived from the Green’s function identity of the Laplace operator and is capable of ......
Hydroxyectoine Metabolism in Halomonas elongata
(2013-04-16)
The marine Gram-negative bacterium Halomonas elongata is known to produce hydroxyectoine (8), a molecule that is valuable because of its broad spectrum of potential industrial applications. However, the widespread use of ......
Impact of neuronal CPEB2 on the translation of mRNAs involved in synaptic plasticity
(2013-05-22)
Among four members of the CPEB family, much less information is available for CPEB2. Although the expression of CPEB2 has been reported in mouse brain (Theis et al., 2003; Hagele et al., 2009; Turimella et al., in revision), ...
Formation Navigation and Relative Localisation of Multi-Robot Systems
(2013-05-07)
When proceeding from single to multiple robots, cooperative action is one of the most relevant topics. The domain of robotic security systems contains typical applications for a multi-robot system (MRS). Possible scenarios ...