The Faculty of Mathematics and Natural Sciences: Search
Now showing items 101-110 of 210
Synthese und Untersuchung neuer ABCG2 Inhibitoren
(2017-03-29)
Aufgrund dessen, dass die Überexpression von ABCG2 eine Rolle bei der Entstehung der Multidrug Resistance von Krebszellen spielt wurde die Entwicklung potenter und selektiver ABCG2 Inhibitoren immer wichtiger. Ziel dieser ...
Charakterisierung allosterischer Bindungsstellen von P2X4-Rezeptor-Modulatoren
(2017-04-24)
P2X-Rezeptoren stehen aufgrund ihrer Beteiligung an zahlreichen (patho)physiologischen Prozessen wie der Wahrnehmung von Schmerz, entzündlichen Veränderungen oder Krebs als Zielstrukturen für potentielle neue Wirkstoffe ...
Enzyme-inhibitory secondary metabolites and their exudation in the marine-derived fungus Epicoccum nigrum link
(2017-04-25)
The kingdom of fungi harbors a huge diversity of life forms. The Ascomycota in particular are a prolific source of medicinal drugs and new lead structures with potent bioactivities. During this work, two marine-derived ......
Quiver Modulations and Potentials
(2017-04-11)
We introduce DWZ (Derksen-Weyman-Zelevinsky) mutation for a special class of SPs (species with potential). Generalizing a construction of Labardini-Fragoso, we associate with each triangulated, constantly weighted orbifold ...
Osmotic stress response in the industrially important bacterium Gluconobacter oxydans
(2017-03-24)
G. oxydans is commercially used for the oxidative fermentation of various sugars, sugar acids, and alcohols to produce biotechnologically valuable products. The current study was conducted to explore the (so-far unknown) ......
Stochastic individual-based models of adaptive dynamics and applications to cancer immunotherapy
(2017-03-24)
In this thesis stochastic individual-based models describing Darwinian evolution of asexual, competitive populations are studied. A specialization of these models is developed to describe tumor development under immunotherapy ...
Climate- and Human-Induced Vegetation Changes in Northwestern Turkey and the Southern Levant since the Last Glacial
(2017-04-20)
Northwestern Turkey and the southern Levant are key regions for studying vegetation and climate developments during migration phases of modern humans and the origin and expansion of agriculture. Both regions have a long ...
Rolle des Adaptermoleküls MyD88 im Mausmodell der Lichtalterung und Photokarzinogenese
(2017-03-27)
Die Haut ist eines der größten Barriereorgane des Körpers und schützt diesen vor Pathogenen oder Umwelteinflüssen wie UV-Strahlung. Die chronische Exposition gegenüber UVB-Strahlen induziert die Bildung von sterilen ......
The skin is the first line of defense against pathogens or environmental influences as UVBirradiation. Chronic exposure of UVB-irradiation induces the formation of danger-associated molecular patterns (DAMPs) and leads to ......
The skin is the first line of defense against pathogens or environmental influences as UVBirradiation. Chronic exposure of UVB-irradiation induces the formation of danger-associated molecular patterns (DAMPs) and leads to ......
Physiological and molecular studies of different aldehyde dehydrogenase (ALDH) genes in response to high temperature and functional analyses of the ALDH7B4 promoter in Arabidopsis thaliana
(2017-04-06)
In this study, the function of aldehyde dehydrogenase (ALDH) genes in response to heat stress alone and in combination with dehydration, salinity, or wounding stress was investigated using selected ALDH genes ...
Intuitive Exploration of Multivariate Data
(2017-07-03)
Approaching a dataset with an analysis question is usually not a trivial process. Apart from integrating, cleaning and pre-processing the data, typical issues are to generate and validate hypotheses, to understand which ...