The Faculty of Mathematics and Natural Sciences: Search
Now showing items 181-190 of 210
A phase-field model of dislocations on parallel slip planes
(2017-03-10)
We expand the Peierls-Nabarro phase-field model of dislocations on one active slip plane introduced by Koslowski, Cuitiño, and Ortiz to the case of multiple parallel slip planes embedded into a homogeneous anisotropic ...
Patientenspezifische induziert pluripotente Stammzellen als Modellsystem zur Untersuchung der lysosomalen Speichererkrankung Metachromatische Leukodystrophie
(2017-01-04)
Die Metachromatische Leukodystrophie (MLD) wird verursacht durch eine funktionelle Defizienz des metabolischen Enzyms Arylsulfatase A (ARSA). Unter physiologischen Bedingungen baut ARSA das Membranlipid 3’-O-Sulfo-Galakt ......
Generierung und Charakterisierung eines in vivo Modells zur BAG3P209L-Mutation im Herzmuskel
(2017-01-04)
Myofibrilläre Myopathien sind Erkrankungen der Muskulatur mit teilweiser Beteiligung der Herzmuskulatur, die oft einen frühzeitigen Tod zur Folge haben. Dabei macht sich das Leitsymptom einer Myofibrillären Myopathie, eine ......
Learning Object Recognition and Object Class Segmentation with Deep Neural Networks on GPU
(2017-02-14)
As cameras are becoming ubiquitous and internet storage abundant, the need for computers to understand images is growing rapidly. This thesis is concerned with two computer vision tasks, recognizing objects and their ...
Biological functions of Sphingomyelin synthase related protein and Ceramide synthase 4 investigated with transgenic mouse mutants
(2017-01-04)
Previously, it was reported that the catalytic activity of the sphingomyelin synthase related protein (SMSr) is essential to prevent ceramide accumulation and disruption of the early secretory pathway in cultured HeLa ...
Error analysis of regularized and unregularized least-squares regression on discretized function spaces
(2017-01-04)
In this thesis, we analyze a variant of the least-squares regression method which operates on subsets of finite-dimensional vector spaces.
In the first part, we focus on a regression problem which is constrained to ...
In the first part, we focus on a regression problem which is constrained to ...
Membrane-model systems to study EGFR-ARNO interaction
(2017-01-04)
Transmembrane proteins are involved in important biological functions, such as in transport of molecules, and in signal transduction. They represent almost 25 % of the proteome and constitute important drug targets. The ...
Analysis of the natural product biosynthesis in gliding bacteria using in vitro assays
(2017-01-10)
Natural products are most important in drug discovery and therapy, e.g. more than 80% of antibiotics are derived from microorganisms. Antimicrobial resistance is a global threat and thus an urgent need for new antimicrobial ...
Transformative Adaptation and Natural Resource Management Interventions in North Eastern Ethiopia
(2017-01-04)
This study is motivated by the observation that adaptation to climate change is often presented as a technical problem that requires only engineering and technological solutions. What is missing from current adaptation ...
Search for Supersymmetry with Hadronically and Leptonically Decaying Tau Leptons at the ATLAS Experiment
(2017-01-20)
The search for physics beyond the Standard Model (SM) is a central focus of modern particle physics. Supersymmetric extensions (SUSY) to the SM offer elegant solutions to many unresolved questions of the theory. This thesis ...