The Faculty of Mathematics and Natural Sciences: Search
Now showing items 21-27 of 27
Mass Spectrometric Profiling of Lysosomal Protein Interactions, Structures, and Half-lives via Cross-Linking and Pulse Stable Isotope Labeling
(2022-07-08)
In mammalian cells, the lysosome is the central organelle for the degradation of macromolecules and recycling of their building blocks. Mutations in almost every known lysosomal hydrolase lead to a group of rare but ...
Computation of Mass Spectra Using Quantum Chemical Methods
(2022-11-23)
Mass spectrometry (MS) is widely used for the structural elucidation of compounds in a vast variety of scientific research. Unfortunately, many methods that aim to predict mass spectra cannot often elucidate the complete ...
From Density Functional Theory to Tight Binding: Development of Robust and Efficient Quantum Chemistry Methods
(2022-12-07)
The main topics of this thesis are efficient quantum chemical methods, their development, and the verification using existing and newly devised benchmark sets. The spectrum of quantum chemical methods discussed here includes ...
On the importance of meteorological parameters in processes affecting the chemical composition of the tropsphere
(2022-12-22)
Investigating the interaction of meteorology and chemistry in the troposphere is important for the identification of the processes which drive the evolution of tropospheric composition in a changing climate. It does not ...
Identification and pharmacological characterization of nucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) and -4 (NPP4) inhibitors
(2022-07-29)
Ectonucleotidases are enzymes involved in different physiological functions and mainly in the regulation of purinergic signaling; in fact, they regulate the duration of purinergic receptor activation by catalyzing the ...
Selbstassemblierte Monolagen organischer Moleküle auf Festkörperoberflächen
(2022-08-22)
Im Rahmen der vorliegenden Arbeit wurden selbstassemblierte Monolagen organischer Moleküle an der Fest-Flüssig-Grenzfläche von Graphit mittels Rastertunnelmikroskopie untersucht. Die Arbeit verfolgte das Ziel, das Verständnis ......
Design, synthesis and optimization of receptor ligands: tools for studying purine-activated and related orphan G protein-coupled receptors
(2022-04-01)
Adenosine receptors
The A2A and A2B adenosine receptors (ARs) are promising drug targets in Alzheimer´s and Parkinson´s disease, inflammatory diseases, autoimmune diseases, ...
The A2A and A2B adenosine receptors (ARs) are promising drug targets in Alzheimer´s and Parkinson´s disease, inflammatory diseases, autoimmune diseases, ...