Mathematisch-Naturwissenschaftliche Fakultät: Suche
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Identification of Quantitative Trait Loci in Alcoholism
(2009-07-20)
The aim of the present study was the identification of chromosomal loci that contribute to the development and manifestation of behaviours related alcohol drinking and alcohol withdrawal. For this purpose, a serial behavioural ...
Study of Human-Specific Microglial Receptor Siglec-11 and Generation of Transgenic Mice Expressing Human Siglec-11
(2009-07-07)
Siglec-11 is a recently identified human-specific CD33-related Siglec expressed on microglia. The full-length cDNA of Siglec-11 encodes 5 extracellular Ig-like domains, a single pass transmembrane domain, and a cytosolic ...
Cell-cell adhesion mediated by mobile receptor-ligand pairs: a biomimetic study
(2009-05-07)
This thesis aims at a quantitative understanding of the physical processes in cell-cell adhesion caused by mobile cell adhesion molecules. To unequivocally separate physical processes from active biological cell response, ...
Marine-derived fungi: a source for structurally new and bioactive secondary metabolites
(2009-05-25)
The marine habitat has been proven to be a rich source for both macro- and microorganisms that produce novel and often highly bioactive natural products. Hence, the investigation of the secondary metabolite spectrum of ...
Charakterisierung der Induktion von CD8 T Zell-Immunität durch sinusoidale Endothelzellen der Leber
(2009-06-19)
Die Leber spielt eine entscheidende Rolle bei der Induktion der peripheren Toleranz. Hierbei sind die sinusoidalen Endothelzellen der Leber (LSEC) von großer Bedeutung, welche mit CD8 T Zellen interagieren und in diesen T ...
Identification and characterization of novel keratin associated proteins using a genetic interaction screening system
(2009-07-21)
Keratins are an integral and important constituent of the epithelial cytoskeleton and protect epithelial cells against stress. In addition to their well-established function as cytoskeletal scaffolds in epithelia, recent ...
Lineage Selection and Enhanced Tissue Integration of Functional and Cryopreservable Human Embryonic Stem Cell-Derived Neurons
(2009-05-13)
In this study, a human Doublecortin (DCX) promoter-based lineage selection strategy is presented for the generation of purified human embryonic stem (hES) cell-derived immature neurons. Stable transfection of long-term ...
Biochemical and functional analysis of innexin2-containing gap junction channels during organogenesis in Drosophila
(2009-05-13)
Gap junctions channels serve as mediators for direct cell-to cell communication between cells of different tissues and organs by the exchange of small metabolites and signalling molecules. They are formed by analogous ...
Der Einfluss von Ca2+-Ionen auf die Aktivität von Mersacidin und Mersacidin-ähnlichen Lantibiotika
(2009-05-08)
Das Typ-B-Lantibiotikum Mersacidin entfaltet seine antibakterielle Aktivität, indem es spezifisch über ein konserviertes Bindemotiv mit der ultimativen Zellwandvorstufe Lipid II interagiert und dadurch den Transglykosyli ...
Lypd6: Ein neuartiger Modulator neuronaler nikotinischer Acetylcholinrezeptoren
(2009-05-15)
Nikotinischce Acetylcholinrezeptoren (nAChRs) zeigen für unterschiedliche Agonisten spezifische Sensitivitäten und Desensitisierungskinetiken. Diese Rezeptoreigenschaften können z.B. durch Schlangenneurotoxine oder den ...