The Faculty of Mathematics and Natural Sciences: Search
Now showing items 41-48 of 48
Deciphering the functional role of the LIS1/NDEL1/14.3.3ε protein complex in the expansion of human cortical progenitors in an iPSC-derived organoid model
(2021-07-19)
The human brain is an exceptionally complex organ, both structurally and functionally, and represents the most remarkable progress in evolution. The human cortex is a highly organised and extensively folded structure ...
Relevance of cGAMP-mediated bystander cell activation and cooperation of cGAS and TLR signaling in TREX1-related autoimmunity
(2020-11-05)
The aberrant recognition of endogenous nucleic acids by innate immune sensors can trigger a wide range of autoimmune and autoinflammatory conditions, mediated by type I interferons. Laoss-of-function mutations in the three ......
Bedeutung der cGAMP-vermittelten Bystander-Zellaktivierung und der Kooperation von cGAS- und TLR-Signalwegen bei TREX1-assoziierter Autoimmunität
Entwicklung von Autoinflammation und Autoimmune ......
Bedeutung der cGAMP-vermittelten Bystander-Zellaktivierung und der Kooperation von cGAS- und TLR-Signalwegen bei TREX1-assoziierter Autoimmunität
Entwicklung von Autoinflammation und Autoimmune ......
Funktionelle Untersuchungen des ABC-Transporters ABCG2
(2021-10-15)
Das Phänomen der Multidrug Resistance (MDR) stellt ein bedeutsames Problem bei der Behandlung von Tumoren mit Chemotherapeutika dar. Die ABC-Transporter ABCB1, ABCC1 und ABCG2 sind an der Entstehung der MDR beteiligt. ...
Direct lineage programming - a tool to generate and analyze human cortical layer specific neurons
(2020-05-14)
Until recently, lineage commitment and differentiation have been considered to be unidirectional and irreversible. This traditional view has dramatically changed with the advent of cellular reprogramming and direct cell ......
Functional in vivo calcium imaging in the hippocampus under healthy and disease conditions
(2020-04-22)
The hippocampus has long been known to be essential for all features of memory processing. Hippocampal function strongly depends on the orchestrated activity of transiently autonomous neuronal populations that create the ......
Creld1 controls T cell homeostasis in mouse and human
(2020-07-07)
Cysteine-rich with EGF-like domains 1 (Creld1) was recently found to be fundamental for the VEGF-mediated activation of NFATc1 during heart development. Creld1 complete KO in mice is lethal due to developmental problems ...
Fluorescent proteins for two-photon FLIM analysis of presynaptic protein interactions
(2020-06-10)
Monitoring Förster Resonance Energy Transfer (FRET) between fluorescent proteins (FPs) fused to proteins of interest is a powerful approach to study dynamic interactions of cellular proteins in living cells. The choice of ...
Activation Mechanisms of RIG-I
(2020-11-02)
(noch nicht zugänglich / not yet accessible)