Mathematisch-Naturwissenschaftliche Fakultät: Suche
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Regulation of inflammasome activation: roles for phospholipase C and mitochondria
(2021-08-05)
Inflammasomes are protein complexes serving as activation platforms for the protease caspase-1, which leads to a pro-inflammatory type of cell death termed pyroptosis and to maturation and release of the cytokines interleukin- ......
I) Characterization of LytR-CpsA-Psr enzymes and their role in Staphylococcus aureus cell wall formation
II) Elucidating the mode of action of Cacaoidin, a novel class V lantibiotic
(2022-04-04)
Antibiotic resistance poses a serious threat to human health, demanding for the discovery and development of antibiotics with resistance-breaking properties. New antibiotics should be sought with the focus on novel chemistry ...
Carvedilol-mediated signal transduction at the β2 adrenergic receptor
(2022-07-14)
G protein-coupled receptors (GPCRs) comprise the most prominent family of membrane proteins in the mammalian genome. They are required to relay extracellular cues into a cellular response. The environmental interactions ...
Contribution of resident macrophages to the fetal liver hematopoietic stem cell niche
(2022-07-29)
Tissue-resident macrophages are a heterogeneous population of phagocytes found in almost all tissues of the body. Recent studies indicate that most resident macrophages originate from yolk sac progenitors and are maintained ...
Keeping in Touch: Visualising and Perturbing Photorespiratory Organelle Proximity in Plants
(2023-12-06)
Organelles within cells are typically depicted as isolated structures, but increasing evidence shows that they are interconnected via specific membrane contact sites (MCS). While MCS research in mammals and yeast is gaining ...
TREM2 modulates differential deposition of post-translationally modified Aβ variants in the brain parenchyma and the vasculature
(2022-08-01)
Alzheimer’s disease (AD) is characterized by the combined presence of extracellular amyloid-beta (Aβ) plaques and intracellular neurofibrillary tangles (NFTs) with abnormally phosphorylated tau (t) protein in the ...
Function of RIM4 in cerebellar circuits
(2023-12-18)
(noch nicht zugänglich / not yet accessible)
Lipid II-binding antibiotics – differential antibiotic activities beyond sequestration of the central peptidoglycan precursor
(2023-04-28)
(noch nicht zugänglich / not yet accessible)
Elucidation of multinumerous centrosomes and their impact on migration in dendritic cells
(2023)
Centrosomes act as major microtubule organizing center (MTOC) in most animal cells and are well known for their role in building up the mitotic spindle during cell division. Core structure of the centrosome are two tubulus ...
Molecular determinants of prostate cancer aggressiveness: an analysis of the interconnection between biomarkers,disease drivers and resistance mechanisms towardsnovel diagnostic, theranostic and therapeutic approaches
(2023-06-21)
The diagnosis of prostate cancer (PCa) is still mainly based on morphological criteria but is supported by biomarker analysis, which is currently mainly performed on an immunohistochemical basis. Newly developed techniques ......