The Faculty of Mathematics and Natural Sciences: Search
Now showing items 11-20 of 22
Evaluating onco-geriatric scores and medication risks to improve cancer care for older patients
(2020-03-19)
The cancer therapy of older patients is challenging, being more complex than the therapy of younger patients. Older cancer patients show a higher toxicity risk during therapy and drug-related problems are common. In order ...
Pharmacological reprogramming of macrophages through aptamiRs
(2020-03-05)
Nucleic acid-based molecules have certain advantages over conventional drugs or protein-based target approaches. Chemically synthetized nucleic acids-based molecules are known as aptamers. They are selected from a combinatorial ...
Biochemical and structural characterization of the NLRP3 inflammasome
(2020-02-13)
The innate immune system utilizes inflammasome proteins to recognize danger signals and to fight invading pathogens. To date, the most studied inflammasome protein is NLRP3 - a multidomain protein, composed of a N-terminal ...
Characterization of Ceramide synthase 2 dysfunctions caused by targeted mutations in transgenic mice
(2020-02-10)
Ceramide species are the precursor of sphingolipids, which serve as structural components of biological membranes or are bioactive molecules. In mammals, ceramides are synthesised by a family of ceramide synthases (CerS) ......
Locus coeruleus modulates locomotor activity via the medial septum and the diagonal band of Broca
(2020-10-02)
The locus coeruleus (LC) is positioned in the brainstem and one of the main sources of norepinephrine in the brain. With its projections throughout the whole brain, the LC plays an important role in regulating the general ...
Relevance of cGAMP-mediated bystander cell activation and cooperation of cGAS and TLR signaling in TREX1-related autoimmunity
(2020-11-05)
The aberrant recognition of endogenous nucleic acids by innate immune sensors can trigger a wide range of autoimmune and autoinflammatory conditions, mediated by type I interferons. Laoss-of-function mutations in the three ......
Bedeutung der cGAMP-vermittelten Bystander-Zellaktivierung und der Kooperation von cGAS- und TLR-Signalwegen bei TREX1-assoziierter Autoimmunität
Entwicklung von Autoinflammation und Autoimmune ......
Bedeutung der cGAMP-vermittelten Bystander-Zellaktivierung und der Kooperation von cGAS- und TLR-Signalwegen bei TREX1-assoziierter Autoimmunität
Entwicklung von Autoinflammation und Autoimmune ......
Direct lineage programming - a tool to generate and analyze human cortical layer specific neurons
(2020-05-14)
Until recently, lineage commitment and differentiation have been considered to be unidirectional and irreversible. This traditional view has dramatically changed with the advent of cellular reprogramming and direct cell ......
Functional in vivo calcium imaging in the hippocampus under healthy and disease conditions
(2020-04-22)
The hippocampus has long been known to be essential for all features of memory processing. Hippocampal function strongly depends on the orchestrated activity of transiently autonomous neuronal populations that create the ......
Creld1 controls T cell homeostasis in mouse and human
(2020-07-07)
Cysteine-rich with EGF-like domains 1 (Creld1) was recently found to be fundamental for the VEGF-mediated activation of NFATc1 during heart development. Creld1 complete KO in mice is lethal due to developmental problems ...