Mathematisch-Naturwissenschaftliche Fakultät: Suche
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High fat diet modulates conventional dendritic cell development through Interferon regulatory factor 8
(2022-07-21)
During obesity-associated inflammation, myeloid cells play an essential role in initiating and maintaining inflammation during diet-induced obesity. In recent years, more evidence has linked conventional dendritic cell ...
Electric Imaging in Weakly Electric Fish and Biomimetic Devices
(2022-08-03)
The nocturnal and weakly electric fish Gnathonemus petersii inspects its murky habitats by self-generated electric signals; an adaption called active electrolocation, enabled by the fish's active electric sense. Animals, ......
Electric Imaging – Aktive Elektroortung in schwach elektrischen Fischen und bionischen Sensoren
Der nachtaktive und schwach elektrische Fisch Gnathonemus petersii besitzt einen aktiven elektrischen ......
Electric Imaging – Aktive Elektroortung in schwach elektrischen Fischen und bionischen Sensoren
Der nachtaktive und schwach elektrische Fisch Gnathonemus petersii besitzt einen aktiven elektrischen ......
Synthesis and structure-activity relationships of CD39 and CD73 inhibitors
(2022-08-13)
Ecto-nucleoside triphosphate diphosphohydrolase-1 (NTPDase1 or CD39) is a member of the membrane-bound ecto-nucleotidase family, which catalyzes the extracellular hydrolysis of pro-inflammatory ATP and pro-thrombotic ADP ......
Targeting nucleic acid receptors to improve filarial vaccination in the Litomosoides sigmodontis model
(2022-10-27)
Lymphatic filariasis and onchocerciasis (river blindness) are human filarial diseases, which put a high socio-economic burden on endemic countries. Until now no vaccination is available, which could greatly aid elimination ......
The role of the transcription factor BCL11A in midbrain dopaminergic neurons
(2022-03-11)
Midbrain dopaminergic (mDA) neurons are located in three midbrain nuclei, the substantia nigra (SN), ventral tegmental area (VTA) and retrorubral field (RRF). mDA neurons are diverse in their developmental origin, their ......
Dopaminerge Neuronen des Mittelhirns (mDA) befinden sich in drei Kerngebieten des Mittelhirns, der Substantia nigra (SN), dem ventralen tegmentalen Areal (VTA) und dem retrorubralen Feld (RRF). mDA-Neurone unterscheiden ......
Dopaminerge Neuronen des Mittelhirns (mDA) befinden sich in drei Kerngebieten des Mittelhirns, der Substantia nigra (SN), dem ventralen tegmentalen Areal (VTA) und dem retrorubralen Feld (RRF). mDA-Neurone unterscheiden ......
Synthesis and characterisation of novel isoform-selective histone deacetylase inhibitors (HDACi) and HDACi-based multi-target ligands
(2022-04-26)
In the quickly evolving field of epigenetic therapy, histone deacetylases (HDACs) have emerged as preferred targets for the treatment of cancer and other conditions such as viral infections, neurodegenerative disorders, ...
Einfluss der zellspezifischen Deletion des miR-17~92-Clusters auf die Entwicklung des Kleinhirns
(2022-06-28)
Seit der Entdeckung der ersten micro-Ribonukleinsäure (miRNA/miR) wurde intensiv an der Funktion von miRNAs bei der Entwicklung des Kleinhirns geforscht. Dennoch sind die Mechanismen, über die miRNAs die beteiligten ...
Targeting aberrant dendritic integration to treat cognitive comorbidities of epilepsy
(2022-07-07)
Memory deficits are one of the most debilitating and common symptoms of temporal lobe epilepsy. However, so far, little is known about mechanisms underlying cognitive deficits and how pharmacologically target them. In most ...
A light-dependent aptamer-photoreceptor system enables spatiotemporal control of RNA biochemistry
(2022-07-29)
Light plays an important role in all kingdoms of life and regulates processes such as plant growth, flowering or vision in complex life forms. The growing field of optogenetics harnesses those properties by combining them ...
Irreversible Antagonists for the Adenosine A2B Receptor
(2022-06-13)
Blockade of the adenosine A2B receptor (A2BAR) represents a potential novel strategy for the immunotherapy of cancer. In the present study, we designed, synthesized, and characterized irreversible A2BAR antagonists based ...