Mathematisch-Naturwissenschaftliche Fakultät: Suche
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Radialgliaähnliche Vorläuferzellen aus pluripotenten Stammzellen: ein stabiles Intermediat zur effizienten Generierung humaner Oligodendrozyten
(2017-09-12)
Als myelinproduzierende Zellen spielen die Oligodendrozyten eine essenzielle Rolle für die Funktionalität des Zentralnervensystems (ZNS). Sie bilden die isolierenden Myelinscheiden der Neurone und garantieren so eine ...
Concentration Dependent Ion–Protein Interaction Patterns Underlying Protein Oligomerization Behaviours
(2017-07-27)
Most proteins do not exist as monomers. Instead, proteins assemble into oligomeric structures, which range from small dimers to intermediately sized clusters to large polymers. Oligomerization is driven by protein–protein ...
Functional regions within a Q/N rich prion domain driving prion replication in the mammalian cytosol
(2017-05-15)
Prions are proteinaceous infectious agents that replicate by recruiting and converting homotypic soluble proteins into growing aggregates. Prions in mammals cause transmissible spongiform encephalopthies and are composed ...
The orphan G protein-coupled receptor GPR17: its pharmacology and function in recombinant and primary cell expression systems
(2017-04-26)
The reconstitution of myelin sheaths, so called remyelination, represents an innovative therapeutic goal in multiple sclerosis (MS), the most common inflammatory-demyelinating disease of the central nervous system (CNS). ...
Immune regulation in Plasmodium berghei ANKA infected mice either lacking type I interferon signalling or mimicking malaria tolerance
(2017-03-16)
Malaria is a disease caused by Plasmodium parasites and transmitted by female Anopheles mosquitoes. Children under the age of five, pregnant women and none-immune individuals are at risk of developing severe malaria such ......
Malaria ist eine Krankheit, die durch eine Infektion mit Parasiten der Gattung Plasmodium entsteht und durch weibliche Anopheles Mücken übertragen wird. Besonders Kinder unter 5 Jahren, schwangere Frauen und nicht-immune ......
Malaria ist eine Krankheit, die durch eine Infektion mit Parasiten der Gattung Plasmodium entsteht und durch weibliche Anopheles Mücken übertragen wird. Besonders Kinder unter 5 Jahren, schwangere Frauen und nicht-immune ......
Diversity and Evolutionary Origin of the Virus Family Bunyaviridae
(2017-01-17)
The family Bunyaviridae is one of the largest groups of viruses and contains more than 350 taxa. Five genera are assigned to the family, namely Hantavirus, Nairovirus, Orthobunyavirus, Phlebovirus, and Tospovirus. Most ......
Patientenspezifische induziert pluripotente Stammzellen als Modellsystem zur Untersuchung der lysosomalen Speichererkrankung Metachromatische Leukodystrophie
(2017-01-04)
Die Metachromatische Leukodystrophie (MLD) wird verursacht durch eine funktionelle Defizienz des metabolischen Enzyms Arylsulfatase A (ARSA). Unter physiologischen Bedingungen baut ARSA das Membranlipid 3’-O-Sulfo-Galakt ......
The importance of endogenous cannabinoids in stress-related disorders and depression
(2017-02-03)
The endogenous cannabinoid system (ECS) is a unique neuromodulatory system, essentially involved in a variety of physiological processes. It consists of the two major endogenous cannabinoids (eCBs), anandamide and 2-AG, ......
Characterization of Staphylococcus aureus antigen-specific antibodies and application of their epitopes as active vaccine against MRSA
(2017-09-21)
Patients infected with the life-threatening, methicillin-resistant, human pathogen Staphylococcus aureus (MRSA) can be treated only with antibiotics of last resort. The development of a vaccine as an alternative to antibiotics ......
The immunomodulatory capacity of helminths on inflammation: Impact of eosinophils on E. coli-induced sepsis and genome-wide transcriptome profiling of human monocytes stimulated with helminth extract and LPS implicate immune functions and diseases
(2017-10-19)
Human filarial nematode infections cause lymphatic filariasis and onchocerciasis in more than 150 million people worldwide. An infection can result in debilitating clinical manifestations like visual impairment or lymphedema ......