The Faculty of Mathematics and Natural Sciences: Search
Now showing items 51-60 of 159
The role of T helper 17 cells in the Pathogenesis of Human Onchocerciasis
(2015-03-31)
Onchocerciasis, also known as river blindness, is a tropical disease causing health and socioeconomic problems in endemic communities, especially sub-Saharan Africa. The disease is elicited by a filarial parasite called ......
Untersuchung des Einflusses des Endocannabinoidsystems auf das Schicksal, die Funktion und die Interaktion kardialer Zellen in vitro und in vivo
(2015-01-19)
Diverse Arbeiten demonstrieren den Einfluss des Endocannabinoidsystems (ECS) auf regulatorische Mechanismen im ischämischen Myokard. Besonders der Cannabinoidrezeptor 2 (CB2R) scheint an diesen Prozessen zu partizipieren ......
Molecular mechanisms underlying presynaptic plasticity: characterization of the RIM1α and SV2A interactome
(2015-02-11)
Synaptic plasticity encompasses various cellular mechanisms, which confer synapses the ability to react and adapt to ongoing changes in network activity. Some of the suggested mechanisms include remodelling and/or assembly ...
Synthesis of ganglioside and lysoganglioside lipoforms as internal standards for MS quantification
(2015-01-08)
The goal of this work was to establish methods for the synthesis of modified gangliosides that are suitable as internal standards for mass spectrometry. Quantification of gangliosides is usually achieved by staining after ...
New bioactive metabolites from the marine-derived fungus Dichotomomyces cejpii and their pharmacological relevance
(2015-01-13)
Natural products from fungal sources provide an astonishing diversity of bioactive molecules. The secondary metabolite production in fungi is strongly affected by environmental influences and the isolation of fungal strains ......
Investigation of two different aspects of stem cell biology: The role of Stat3 signaling and innate immunity in human pluripotent stem cells
(2015-01-08)
Human pluripotent stem cells (hPSCs) hold great promises as a model for development as well as a source for cells in regenerative medicine. Although hPSC research came into focus in the last decade, many aspects of the ...
Neuropeptides in stress reactivity: Role of enkephalin in response to chronic stress
(2015-01-29)
The incidence of mood pathologies, such as chronic anxiety and major depression, is a serious health problem in modern societies. The knowledge about the molecular mechanisms involved in the development of these disorders ...
Microglial sialic-acid-binding immunoglobulin-like lectin-H (Siglec-H) and Siglec-11 in neuroinflammation
(2015-01-16)
Sialic acid binding Siglecs are involved in various pathological processes. A minor fraction of Siglecs mediates activating signals via the ITAM linked DAP12 adaptor protein while the majority of Siglecs modulates inflammatory ......
Role of antimicrobial peptides in metabolism and innate immunity in Drosophila melanogaster
(2014-08-12)
“Metabolism” and “Immunity” are two essential, recognized and independent functions of animal kingdom. They have their own biological cycle independent of each other. While metabolism contributes, amongst other things, to ...
Acceleration of microglial clearance function by small TREM2-activating anionic disaccharides
(2014-07-29)
Triggering receptor expressed on myeloid cells-2 (TREM2) is an innate immune receptor, which is expressed on myeloid cells, like microglia inside the central nervous system. TREM2 signals via the adaptor protein DAP12. ...