The Faculty of Mathematics and Natural Sciences: Search
Now showing items 71-80 of 159
Metabolom- und Transkriptom-Analysen zur Charakterisierung von pflanzlichen Substanzen und daraus hergestellten Zubereitungen = Metabolomic and Transcriptomic Analyses in the Characterization of Herbal Substances and their Preparations
(2014-09-02)
Herbal substances and preparations thereof have been applied and used worldwide throughout human history. Regarding regulatory affairs, the quality assessment of herbal substances and their preparations is mandatory. Quality ...
Lokaler Gentransfer und Zellpositionierung mittels magnetischer Nanopartikel für die Generierung optogenetischer und biologischer Herzschrittmacher
(2014-10-17)
Herzrhythmusstörungen sind Unregelmäßigkeiten der Herzfrequenz, welche für die erkrankten Patienten eine vitale Gefährdung darstellen und sogar tödlich verlaufen können. Ursachen liegen häufig in Störungen des Erregungsbildungs- ...
The Parkinson’s disease-related kinase Pink1 mediates mitochondrial quality control
(2016-08-29)
Mitochondrial dysfunction is a common feature of many neurodegenerative diseases, in particular Parkinson’s disease (PD). Mutations in the genes encoding the mitochondrial kinase Pink1 and the cytosolic E3 ubiquitin ligase ...
Biosynthesis of soluble capsule precursors in Staphylococcus aureus
(2016-11-28)
Most invasive pathogens produce polysaccharide capsules, which play an essential role in conferring protection against host immune defense. In the case of Staphylococcus aureus, most clinical isolates are encapsulated, and ......
Chelation as a strategy with the potential to overcome multidrug resistance in cancer
(2016-09-02)
According to the World Health Organisation cancer is the second leading cause of death in industrialized countries. In many cases treatment fails due to the development of resistance against multiple (structurally and ...
Analysis of human T lymphocyte-derived immune responses against Staphylococcus aureus by delivery of in vitro transcribed antigens
(2016-07-06)
Staphylococcus aureus is a harmless commensal of the human mucosa and at the same time the main cause of life-threatening nosocomial infections worldwide. In particular, the growing number of methicillin-resistant S. aureus ...
Der Einfluss physiologischer Sauerstoffkonzentrationen auf natürliche Killerzellen bei der Hepatitis C Virus- und der Humanes Immundefizienzvirus-Infektion
(2016-07-21)
Natürliche Killerzellen (NK-Zellen) spielen als wichtiger Bestandteil des innaten Immunsystems eine zentrale Rolle bei Viruserkrankungen, so auch der Hepatitis C Virus (HCV)- und der Humanes Immundefizienzvirus (HIV)-Infektion. ...
Molekulare Mechanismen TNF-vermittelter viraler Hepatitis
(2016-06-10)
Zytotoxische T-Lymphozyten (CTL) eliminieren selektiv Virus-infizierte Zellen, indem sie sie anhand von viralem Antigen erkennen, das auf deren Oberfläche präsentiert wird. Eine Ausnahme bildet eine kürzlich entdeckte ...
New inhibitory pathways in CD8 T cell function
(2016-06-07)
An adaptive immune response is initiated upon recognition of antigen presented on the surface of antigen-presenting cell (APC) by T cells. CD8 T cells primed in the liver by antigen-presenting liver sinusoidal endothelial ......
The Control of Food Intake and Bitter Taste Information Processing in the Drosophila Larval Brain
(2016-12-22)
The regulation of feeding behavior by central neural circuits is crucial for every organism to survive. Hierarchical organized motor systems are responsible for the execution of appropriate feeding movements and can be ...