The Faculty of Mathematics and Natural Sciences: Search
Now showing items 81-90 of 159
N-glycosylation of intrinsic and engineered N-X-S/T motifs by Pichia pastoris can be exploited to ligate the mannose receptor but reveals no gain in immunogenicity per se
(2016-12-22)
Vaccination has the power to eradicate viral diseases and is a promising approach to cure cancer. However, modern vaccination strategies repeatedly fail in inducing a robust cytotoxic CD8+ T cell response, which ...
Study on the role of Cofilin 2 in the brain
(2016-12-22)
Three actin depolymerization factors are expressed in the brain, named Cofilin 1 (non-muscle Cofilin), ADF and Cofilin 2, which was long declared as muscle-specific isoform. All three members share similar biochemical ...
Functional characterization of Cytoplasmic Polyadenylation Element Binding proteins in the developing and diseased brain
(2016-12-22)
Gliomas are the most common primary brain tumors with aggressive progression and devastating prognosis. Therefore identification of new therapeutic and diagnostic factors is necessary to improve the dramatic situation of ...
Click-SELEX: A versatile approach towards nucleobase-modified aptamers
(2016-11-28)
Aptamers are short nucleic acids that can be selected to bind specifically and with high affinity to a variety of targets, including small organic molecules and proteins. However, for a multitude of targets, traditional ...
Identification of protective immune responses and the immunomodulatory capacity of Litomosoides sigmodontis
(2016-11-29)
Using the mouse model Litomosoides sigmodontis, research focusing on the protective immune responses within the host as well as the immunomodulatory capabilities of filarial infections is possible. The immunomodulatory ......
Oxytocin – the prosocial molecule?: Intranasal oxytocin effects on social approach behavior, social cognition, volitional and emotional ambivalence in healthy human beings
(2015-10-30)
Oxytocin (OXT) is a highly conserved neuropeptide, regarding both its chemical structure and its functionality. It has been traced back at least 700 million years. OXT’s fundamental role lies in reproduction and parenting ...
Chemical modifications of DNA activate the cGAS/STING-signaling pathway even in the presence of the cytosolic exonuclease TREX1
(2015-09-16)
To recognize pathogen threats, the innate immune system is equipped with pattern recognition receptors (PRRs) that bind to and are activated by pathogen-associated molecular patterns (PAMPs). Most PAMPs are conserved across ...
Immune modulation by experimental filarial infection and its impact on E. coli-induced sepsis
(2015-11-12)
Helminths cause so-called neglected tropical diseases in tropical and sub-tropical regions and are prevalent in almost one third of mankind. Thus, co-infections of helminths with other pathogens are common. However, the ......
Structural and Functional Characterization of Neurotoxic Oligomers of Pro-aggregant Tau Repeat Domain: A model for Tauopathy disease
(2016-04-26)
Tau protein is a microtubule associated protein present abundantly in the neurons of the central nervous system where it stabilizes the axonal microtubules thereby providing structural architecture for the axons of neurons. ...
Entwicklung neuer Therapiekonzepte im myxoiden Liposarkom: Die Rolle von Fibroblastenwachstumsfaktor-Rezeptoren und microRNAs
(2016-04-21)
Myxoide Liposarkome gehören zu den häufigsten Weichgewebssarkomen. Ihre Pathogenese ist aber bislang nur unvollständig verstanden und es stehen keine zielgerichteten Therapien zur Verfügung. Die für myxoide Liposarkome ...