The Faculty of Mathematics and Natural Sciences: Search
Now showing items 11-20 of 58
Synthesis and structure-activity relationships of α,β-methylene-ADP derivatives: potent and selective ecto-5-nucleotidase inhibitors
(2015-08-19)
Ecto-5'-nucleotidase (ecto-5'-NT, eN, CD73, EC 3.1.3.5) is a member of the group of ecto-nucleotidases which dephosphorylate extracellular nucleotides. eN catalyzes the dephosphorylation of nucleoside monophosphates and ......
Muskarinische M3-Rezeptoren: Einfluss des orthosterischen / allosterischen Epitops Trp 7.35 auf Ligandbindung, Rezeptoraktivierung und Signalweiterleitung
(2015-08-19)
Muskarinische Acetylcholinrezeptoren (M1-M5) sind G-Protein gekoppelte Rezeptoren, die an einer Vielzahl von physiologischen und pathophysiologischen Prozessen beteiligt sind. M1-, M3- und M5-Rezeptoren koppeln vorwiegend ...
Characterization of Expression and Functional Role of Endothelin-1 and its Receptors in Human Lung Fibroblasts
(2015-07-31)
Background: Background: Airway remodeling and fibrotic alterations are pathological key events determining the long-term outcome of chronic inflammatory and obstructive airway diseases such as lung fibrosis, ...
Anti-Counterfeiting in Global Pharmacovigilance: A Question of Patient Safety
(2015-07-29)
Counterfeit products present a huge problem due to their great number on the market all over the world. In contrast to counterfeit luxury goods, which mainly harm the economy, counterfeit medicinal products pose a serious ...
A multifaceted approach to investigate signal transduction at the receptor and post-receptor level focusing on the modulation of the free fatty acid receptor family
(2015-11-16)
Knowledge about the function and dysfunction of cellular signal transduction is at the very heart of biomedical research since every physiological and pathophysiological process is intimately associated with adequate or ...
T-Zellen mit komplementierenden chimären Antigen-Rezeptoren haben eine erniedrigte Aktivierungsschwelle bei der Erkennung von Antigen-Mustern
(2015-11-16)
Die adoptive Immuntherapie mit chimären Antigen Rezeptor (CAR) modifizierten T Zellen erzielte kürzlich spektakuläre Erfolge in der Therapie leukämischer Erkrankungen, jedoch zeigten sich bei der Behandlung solider Tumore ...
Gene targeting in human pluripotent cell-derived neural stem cells for the study and treatment of neurological disorders
(2015-11-19)
Modern stem cell technology has made remarkable progress in recent years with the discovery of induced pluripotency, enabling the production of any cell type from any person in unlimited quantities, as well as improved ...
Wachstumsverhalten fokaler hepatozellulärer Veränderungen in Putenembryonen und die Wirkung von Sorafenib und Cisplatin auf normale und präneoplastische Zellen
(2014-11-28)
In der vorliegenden Arbeit wurde die Möglichkeit der embryonalen Putenleber als Modell zum Test potenzieller Tumortherapeutika untersucht. Es konnten verlässlich fokale hepatozelluläre Veränderungen (foci of altered ...
Development of Enzyme Replacement and Pharmacological Chaperone Approaches for Therapy of Metachromatic Leukodystrophy
(2015-01-06)
Metachromatic leukodystrophy (MLD) is a monogenic, autosomally recessively inherited lysosomal storage disease. Certain mutations of the arylsulfatase A (ASA) gene cause misfolding or absence of ASA. Physiologically ASA ...
Functional characterization of neuron-NG2 cell synaptic transmission
(2014-09-11)
NG2 cells are nowadays considered as a fourth class of glial cells in the CNS. They express various types of voltage-gated ion channels and neurotransmitter receptors and exhibit the capability to proliferate and differentiate. ...