The Faculty of Mathematics and Natural Sciences: Search
Now showing items 71-80 of 106
Molekulare Mechanismen der prometastatischen Tumorzell-Thrombozyten-Interaktionen während der hämatogenen Metastasierung und ihre Inhibition durch Antikoagulantien
(2020-02-04)
In dieser Arbeit wurden die Mechanismen der prometastatischen Interaktionen zwischen Thrombozyten und Tumorzellen während der hämatogenen Metastasierung betrachtet und untersucht, ob Antikoagulantien die hämatogene ...
Evaluating onco-geriatric scores and medication risks to improve cancer care for older patients
(2020-03-19)
The cancer therapy of older patients is challenging, being more complex than the therapy of younger patients. Older cancer patients show a higher toxicity risk during therapy and drug-related problems are common. In order ...
Pharmacological reprogramming of macrophages through aptamiRs
(2020-03-05)
Nucleic acid-based molecules have certain advantages over conventional drugs or protein-based target approaches. Chemically synthetized nucleic acids-based molecules are known as aptamers. They are selected from a combinatorial ...
Molecular pharmacological analysis of the human MrgD receptor: New insights into signaling
(2021-08-09)
Introduction: MrgD is a member of the MAS-related GPCRs family. It has been proposed to play roles in nociception and cardiovascular control. MrgD has been shown to couple to Gq, Gi, and Gs proteins. The ...
Investigations into side chain assembly and attachment during biosynthesis of the G protein inhibitor FR900359
(2021-06-07)
The natural product FR900359 (FR) selectively inhibits Gaq proteins and thus intracellular signalling of many G protein-coupled receptors. This unique mechanism of action makes FR an indispensable pharmacological tool to ......
Investigation of Quinazoline Derivatives as Inhibitors of Breast Cancer Resistance Protein (BCRP/ABCG2)
(2018-03-12)
The treatment of cancer with chemotherapeutic drugs is strongly limited by intrinsic or aquired resistance of the cancer cells. This is the main reason of a failure of the therapy. The cellular resistance mostly originates ...
The role of guanine nucleotide exchange factors (GEFs) in EGF-receptor signalling: Screening for a small molecule inhibitor of the Rin1-mediated Rab5 activation
(2018-06-04)
The small GTPase Rab5 is a key regulator of early endosomal trafficking. It functions as a molecular switch that can be activated by guanine nucleotide exchange factors (GEFs) and inactivated via hydrolysis of GTP with the ...
Application of population, physiologically based, and semi-physiological pharmacokinetic modeling to assess sources of pharmacokinetic variability in individual drugs
(2020-06-05)
Large inter- and intra-individual variability in the response of drugs causes difficulties for clinicians to choose appropriate dosing regimens to target their therapeutic range. While underexposure might cause sub-therapeutic ...
Pharmakoepidemiologische Untersuchungen zur Risikomodifikation der Demenz durch potenziell inadäquate Medikation bei Älteren
(2022-02-10)
Die Auswirkungen einer Psychopharmaka- bzw. Anticholinergika-Exposition auf die Entwicklung dementieller Erkrankungen sind nicht eindeutig geklärt. Während in der Literatur Hinweise auf einen Zusammenhang zwischen einer ...
Mechanisms of action that contribute to the efficacy of ivy leaves dry extract EA 575®
(2018-12-11)
The ivy leaves dry extract EA 575® is an approved cough remedy distributed in more than 100 countries worldwide. The modes of action for its bronchospasmolytic, secretolytic, and anti-inflammatory effects remain ...