The Faculty of Mathematics and Natural Sciences: Search
Now showing items 381-390 of 430
Application of population, physiologically based, and semi-physiological pharmacokinetic modeling to assess sources of pharmacokinetic variability in individual drugs
(2020-06-05)
Large inter- and intra-individual variability in the response of drugs causes difficulties for clinicians to choose appropriate dosing regimens to target their therapeutic range. While underexposure might cause sub-therapeutic ...
Théorie de Bruhat-Tits, grassmanniennes affines et modèles locaux
(2020-10-02)
Nous développons la théorie de Bruhat-Tits pour les groupes quasi-réductifs sur les corps discrètement valués, henséliens et excellents, qui se quasi-déploient sur l'henselisé strict. Ensuite, cette théorie est appliquée ...
Generation of an RNA sensor to probe glycolysis in living cells via the key metabolite fructose 1,6-bisphosphate
(2021-06-24)
Glycolysis is the cornerstone of cell metabolism and is one of the oldest biochemical pathways known to life. Yet, methods to study glycolysis in single living cells are lacking. The glycolytic intermediate Fructose ...
Deciphering the functional role of the LIS1/NDEL1/14.3.3ε protein complex in the expansion of human cortical progenitors in an iPSC-derived organoid model
(2021-07-19)
The human brain is an exceptionally complex organ, both structurally and functionally, and represents the most remarkable progress in evolution. The human cortex is a highly organised and extensively folded structure ...
Phylogeny and evolution of Adephaga and Neuropterida (Insecta: Holometabola) as inferred from analyses of next-generation sequencing data
(2021-09-17)
Knowing the evolutionary relationships of species is fundamental for comparative studies in biology as well as for biodiversity conservation. The main topic of this thesis is the investigation of phylogenetic relationships ...
Relevance of cGAMP-mediated bystander cell activation and cooperation of cGAS and TLR signaling in TREX1-related autoimmunity
(2020-11-05)
The aberrant recognition of endogenous nucleic acids by innate immune sensors can trigger a wide range of autoimmune and autoinflammatory conditions, mediated by type I interferons. Laoss-of-function mutations in the three ......
Bedeutung der cGAMP-vermittelten Bystander-Zellaktivierung und der Kooperation von cGAS- und TLR-Signalwegen bei TREX1-assoziierter Autoimmunität
Entwicklung von Autoinflammation und Autoimmune ......
Bedeutung der cGAMP-vermittelten Bystander-Zellaktivierung und der Kooperation von cGAS- und TLR-Signalwegen bei TREX1-assoziierter Autoimmunität
Entwicklung von Autoinflammation und Autoimmune ......
Historical Biogeography and Macroevolution of the Atacama Desert Flora
(2020-09-17)
Located in northern Chile, the Atacama Desert is not only one of the oldest deserts but also one of the driest places on earth with hyperarid conditions prevailing since the Miocene or earlier. Despite the extreme conditions ...
Place Identity und gesundheitliches Wohlbefinden: Die Bildung von Identität am Wohnort und ihre salutogenetische Wirkung am Beispiel von Neubaugebieten außerhalb der Stadt
(2021-12-16)
Wohnorte können für uns so bedeutsam sein, dass sie unsere Identität in besonderer Weise beeinflussen. So kann der Ort, an dem wir wohnen und leben, unsere Heimat sein, unsere Identität prägen oder sogar als ein Teil unserer ...
Pharmacokinetic-pharmacodynamic modeling of antibacterial agents in tissues and body fluids
(2020-11-25)
The aim of this thesis was to assess the pharmacokinetic / pharmacodynamics (PK/PD) of anti-bacterial agents in tissues and body fluids through non-linear mixed effects (NLME) modeling.
In the first project, a ...
In the first project, a ...
Approximation Algorithms for the Traveling Salesman Problem
(2021-05-11)
The traveling salesman problem (TSP) is probably one of the best-studied problems in discrete optimization. Given a complete weighted graph with n vertices, the task is to find a tour of minimal length that visits every ...