The Faculty of Mathematics and Natural Sciences: Search
Now showing items 1-10 of 27
Mapping the immune landscape in the alveolar space reveals alterations of multiple macrophage states in chronic obstructive pulmonary disease
(2021-03-26)
Chronic obstructive pulmonary disease (COPD) is ranked among the three leading causes of death worldwide and hence constitutes a significant burden, both medically and financially. The disease is characterized by a poorly ...
Functional analysis of the endocannabinoid system in conditional mouse mutants
(2020-09-04)
In the scope of this thesis conditional knockout mice with a cell-specific deletion of Dagla (diacylglycerol lipase alpha) in neurons, astrocytes or microglia cells were generated, in order to identify the cellular source ...
Die Phyllosphäre als Lebensraum für Bakterien: Mechanismen der Interaktion epiphyller Bakterien mit der pflanzlichen Kutikula
(2020-12-16)
Die Phyllosphäre stellt einen lebensfeindlichen Lebensraum dar. Jedoch gibt es epiphytisch lebende Bakterien, die diesen Lebensumständen entgegenwirken und Mechanismen entwickelt haben, in diesem kargen Lebensraum Nährstoffe ......
Neuroinvasion and cerebral ischemia as possible sources for α-synuclein prions in Parkinson’s disease
(2021-07-13)
In synucleinopathies such as Parkinson’s disease misfolding of α-synuclein, normally a cellular and soluble protein, leads to the accumulation of insoluble protein aggregates and to central nervous system disease (CNS). ...
Implementation of the novel high-throughput Fungal Isolation one step Device method FIND and secondary metabolite extraction from the isolate Heydenia cf. alpina
(2021-07-13)
Fungi are an important source of bioactive metabolites. The cultivation of source organisms is a crucial step in natural product isolation. With standard isolation methods for fungi it is difficult to isolate rare und ...
Functional markers for cerebral norepinephrine deficiency in Alzheimer's disease
(2021-02-17)
Pathological alterations of the locus coeruleus (LC)-norepinephrine (NE) system occur early in the course of Alzheimer’s disease (AD), and manifest in poor attention and distractibility. Cortical NE is released from the ...
AHRD: Automatically Annotate Proteins with Human Readable Descriptions and Gene Ontology Terms
(2021-10-05)
In the postgenomic era it is impossible to annotate the majority of new proteins in any other way than with computational methods. Our tool AHRD automatically annotates proteins with human readable descriptions and Gene ...
The Role of TRIM71 in Male Germ Cell Development
(2020-09-02)
Germ cells are the key to continuation of life as they are the unique cell lineage capable to transfer the complete genetic information to the next generation. Both, infertility and testicular cancers are usually originating ......
Loss of Inhibitory CD33 Signaling Results in Increased Microglial Activation
(2021-06-23)
CD33 is expressed on immune cells of myeloid origin, such as macrophages and microglia. Upon activation, CD33 recruits and activates protein tyrosine phosphatases, which results in attenuation of the activatory signaling ...
Studien zur oxidativen Faltung des Faktor-XIIIa-Inhibitors Tridegin
(2020-11-16)
Diese Dissertation beschäftigt sich mit der umfassenden Charakterisierung des Naturstoffs Tridegin. Dieses cysteinreiche, 66 Aminosäuren lange Peptid ist ein spezifischer Inhibitor des letzten Schrittes der Blutgerinnungskaskade, ......
Studies on the oxidative folding of factor XIIIa inhibitor tridegin
This PhD thesis deals with the detailed characterization of the natural compound tridegin. This cysteine-rich 66mer peptide ......
Studies on the oxidative folding of factor XIIIa inhibitor tridegin
This PhD thesis deals with the detailed characterization of the natural compound tridegin. This cysteine-rich 66mer peptide ......