The Faculty of Mathematics and Natural Sciences: Search
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G protein coupled receptors require active Gαq to mobilize Gi-Gβγ-dependent calcium
(2021-06-23)
The mechanisms by which GPCRs drive calcium mobilization in living cells have been a topic of intense research interest for many years. One such mechanism is the paradigmatic Gi-calcium pathway, which describes how Gβγ ...
Investigations into side chain assembly and attachment during biosynthesis of the G protein inhibitor FR900359
(2021-06-07)
The natural product FR900359 (FR) selectively inhibits Gaq proteins and thus intracellular signalling of many G protein-coupled receptors. This unique mechanism of action makes FR an indispensable pharmacological tool to ......