The Faculty of Mathematics and Natural Sciences: Search
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Influence of disulfide-bonds on structural and functional properties of peptides and proteins - Case studies on FXIIIa inhibitor tridegin and µ-conotoxin PIIIA
(2021-05-28)
Disulfide-bonded peptides have been studied for many decades serving as tools to investigate various biochemical pathways as well as lead structures for drug development for numerous diseases. Among these, the most fatal ...
Investigating 5-HT2A receptors - Development of a fluorescent 5HT2A receptor agonist and elucidation of the effects of St. John's wort extract STW3-IV, hyperforin and hyperoside on 5HT2A receptors
(2021-09-22)
Investigating 5-HT2A receptors - Development of a fluorescent 5HT2A receptor agonist and elucidation of the effects of St. John's wort extract STW3-IV, hyperforin and hyperoside on 5HT2A ...
Modulation der Gαi1/s-Proteinaktivität durch lineare und makrozyklische Peptide
(2021-07-08)
Die vorliegende Dissertation beschäftigt sich mit der Identifizierung und Charakterisierung von peptidischen Modulatoren für die Gαi/s-Proteinaktivität. Die Ga-Untereinheit heterotrimerer G-Proteine ist eine bedeutende ...
Funktionelle Untersuchungen des ABC-Transporters ABCG2
(2021-10-15)
Das Phänomen der Multidrug Resistance (MDR) stellt ein bedeutsames Problem bei der Behandlung von Tumoren mit Chemotherapeutika dar. Die ABC-Transporter ABCB1, ABCC1 und ABCG2 sind an der Entstehung der MDR beteiligt. ...
Synthesis, optimization, and characterization of chromen-4-one and 1,7-phenanthroline derivatives as ligands for the orphan G protein-coupled receptors 35 and 84
(2021-06-21)
G protein-coupled receptors (GPCRs) are ideal drug targets. Their characteristic tissue distribution, marked ligand specificity, and their roles in countless (patho)physiological processes are being exploited by more than ...