Mathematisch-Naturwissenschaftliche Fakultät: Suche
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Role of innate lymphoid cells in type 1-dominated experimental Plasmodium berghei ANKA and type 2-dominated Litomosoides sigmodontis infection
(2021-10-27)
Malaria and filariasis remain among the biggest health problems in the tropics and subtropics, especially in Africa, and in the case of malaria among the ten most frequent causes of death. The parasites that cause malaria ......
Single cell visual psychophysics
(2021-10-05)
On the one hand, the eye is the human being’s window to the world. On the other hand the eye is a window to the human brain enabling noninvasive and in vivo assessment of nervous tissue. With adaptive optics scanning laser ...
CD8 T cell responses during primary and secondary influenza infection - Role of MHC-I expression on non-immune cells
(2021-09-03)
Influenza infection results in strong immune responses in the lung usually leading to clearance of infection and, in some cases, immune pathology with varying degrees of prognosis. CD8 T cells are believed to be one of the ...
Mapping the immune landscape in the alveolar space reveals alterations of multiple macrophage states in chronic obstructive pulmonary disease
(2021-03-26)
Chronic obstructive pulmonary disease (COPD) is ranked among the three leading causes of death worldwide and hence constitutes a significant burden, both medically and financially. The disease is characterized by a poorly ...
Structural aspects of the plasmalemmal Amyloid Precursor Protein cluster
(2021-11-12)
Alzheimer’s Disease (AD) is a major socio-economic threat to health care systems and society in general. Involvement of the amyloid-beta peptide (Aβ) and its parent, the amyloid precursor protein (APP), in AD seemed obvious ...
Langerhans and inflammatory dendritic epidermal cells in atopic dermatitis tolerate Toll-like receptor 2-specific activation
(2021-01-26)
Atopic dermatitis (AD) is a chronic multifactorial inflammatory skin disease. The skin of AD patients shows a significant dysbalance of the microbiome with high colonization of S. aureus, which positively correlates with ...
Neuroinvasion and cerebral ischemia as possible sources for α-synuclein prions in Parkinson’s disease
(2021-07-13)
In synucleinopathies such as Parkinson’s disease misfolding of α-synuclein, normally a cellular and soluble protein, leads to the accumulation of insoluble protein aggregates and to central nervous system disease (CNS). ...
Functional markers for cerebral norepinephrine deficiency in Alzheimer's disease
(2021-02-17)
Pathological alterations of the locus coeruleus (LC)-norepinephrine (NE) system occur early in the course of Alzheimer’s disease (AD), and manifest in poor attention and distractibility. Cortical NE is released from the ...
Loss of Inhibitory CD33 Signaling Results in Increased Microglial Activation
(2021-06-23)
CD33 is expressed on immune cells of myeloid origin, such as macrophages and microglia. Upon activation, CD33 recruits and activates protein tyrosine phosphatases, which results in attenuation of the activatory signaling ...
Simulation of Bone Remodeling Process around Dental Implant During the Healing Period
(2021-07-05)
This interdisciplinary thesis deals with the numerical investigation of bone remodeling around dental implants during the healing period with regard to biomechanical aspects. The aim of the study was to develop algorithms ...