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Identification and pharmacological characterization of nucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) and -4 (NPP4) inhibitors
(2022-07-29)
Ectonucleotidases are enzymes involved in different physiological functions and mainly in the regulation of purinergic signaling; in fact, they regulate the duration of purinergic receptor activation by catalyzing the ...
Computational studies on δ-branch G protein-coupled P2Y and related orphan receptors
(2023-06-26)
G protein-coupled receptors (GPCRs) represent an attractive target for drug development as the modulation of their activity can induce a desired physiological response to treat pathological conditions. Given the knowledge ...
Activation Mechanisms of RIG-I
(2020-11-02)
(noch nicht zugänglich / not yet accessible)
The mesoscale organization of Syntaxin 1A and SNAP25 at the plasma membrane
(2023-03-09)
The plasma membrane is a highly crowded place consisting of a plethora of proteins and lipids, which show a high degree of micropatterning. Most proteins are not homogeneously distributed but concentrated in clusters. ...