The Faculty of Mathematics and Natural Sciences: Search
Now showing items 11-20 of 71
Effect of neural ablation of sphingosine-1-phosphate lyase (SGPL1) in glial cells
(2021-11-24)
Sphingosine-1-phosphate (S1P) is an evolutionarily conserved catabolic intermediate of sphingolipid metabolism that regulates diverse biological processes in the brain, including neural development, differentiation, and ...
Neuroinvasion and cerebral ischemia as possible sources for α-synuclein prions in Parkinson’s disease
(2021-07-13)
In synucleinopathies such as Parkinson’s disease misfolding of α-synuclein, normally a cellular and soluble protein, leads to the accumulation of insoluble protein aggregates and to central nervous system disease (CNS). ...
Implementation of the novel high-throughput Fungal Isolation one step Device method FIND and secondary metabolite extraction from the isolate Heydenia cf. alpina
(2021-07-13)
Fungi are an important source of bioactive metabolites. The cultivation of source organisms is a crucial step in natural product isolation. With standard isolation methods for fungi it is difficult to isolate rare und ...
Function of Reelin Signaling in the Tangential Migration of Dopaminergic Neurons
(2021-01-07)
Midbrain dopaminergic neurons (mDA neurons) are involved in the regulation of voluntary movement, reward behavior and cognitive processes. mDA neurons are born in the floor plate of the ventral midbrain, from where they ...
Functional markers for cerebral norepinephrine deficiency in Alzheimer's disease
(2021-02-17)
Pathological alterations of the locus coeruleus (LC)-norepinephrine (NE) system occur early in the course of Alzheimer’s disease (AD), and manifest in poor attention and distractibility. Cortical NE is released from the ...
AHRD: Automatically Annotate Proteins with Human Readable Descriptions and Gene Ontology Terms
(2021-10-05)
In the postgenomic era it is impossible to annotate the majority of new proteins in any other way than with computational methods. Our tool AHRD automatically annotates proteins with human readable descriptions and Gene ...
Molecular analysis of the plastid-targeted gene and protein (CpPTP-1) associated with desiccation tolerance in the resurrection plant Craterostigma plantagineum
(2021-01-28)
Water scarcity causes drought stress and enormous losses in agricultural production, and consequently this leads to a worldwide food crisis. Craterostigma plantagineumis one of the best studied resurrection plants that is ......
Analyse von periplasmatischen Schwefeltransferasen aus Allochromatium vinosum
(2021-07-19)
Die ersten Schritte der Schwefeloxidation in Allochromatium vinosum finden im Periplasma statt, wo reduzierte Schwefelverbindungen oxidiert und in diesem Zuge Schwefelkugeln aufgebaut werden. Es ist denkbar, dass ...
Loss of Inhibitory CD33 Signaling Results in Increased Microglial Activation
(2021-06-23)
CD33 is expressed on immune cells of myeloid origin, such as macrophages and microglia. Upon activation, CD33 recruits and activates protein tyrosine phosphatases, which results in attenuation of the activatory signaling ...
Simulation of Bone Remodeling Process around Dental Implant During the Healing Period
(2021-07-05)
This interdisciplinary thesis deals with the numerical investigation of bone remodeling around dental implants during the healing period with regard to biomechanical aspects. The aim of the study was to develop algorithms ...