The Faculty of Mathematics and Natural Sciences: Search
Now showing items 11-20 of 48
Functional markers for cerebral norepinephrine deficiency in Alzheimer's disease
(2021-02-17)
Pathological alterations of the locus coeruleus (LC)-norepinephrine (NE) system occur early in the course of Alzheimer’s disease (AD), and manifest in poor attention and distractibility. Cortical NE is released from the ...
Structural and functional characterization of the HPV16 entry platform on the cell surface
(2020-12-16)
Human papillomaviruses (HPV) are small, non-enveloped DNA viruses that infect skin and mucosa tissues. Among the family, HPV16 is one of the most oncogenic subtypes responsible for a variety of cancers, including cervical, ...
Loss of Inhibitory CD33 Signaling Results in Increased Microglial Activation
(2021-06-23)
CD33 is expressed on immune cells of myeloid origin, such as macrophages and microglia. Upon activation, CD33 recruits and activates protein tyrosine phosphatases, which results in attenuation of the activatory signaling ...
Simulation of Bone Remodeling Process around Dental Implant During the Healing Period
(2021-07-05)
This interdisciplinary thesis deals with the numerical investigation of bone remodeling around dental implants during the healing period with regard to biomechanical aspects. The aim of the study was to develop algorithms ...
Eosinophil Extracellular DNA Trap Cell Death (EETosis) occurs as a life-cycle stage-specific response to filariae
(2020-06-25)
Filarial nematodes represent a great burden of human morbidity causing diseases like onchocerciasis and lymphatic filariasis. The lack of a vaccination and a short-term therapy with a macrofilaricidal effect hampers the ......
GPR183 Expression on Pulmonary Conventional Dendritic Cell Type 2 Dictates Subtissular Localisation and Instructs Their Survival via the Thymic Stromal Lymphopoietin (TSLP) – TSLP Receptor (TSLPR) Axis
(2021-07-06)
Introduction: G protein-coupled receptor 183 (GPR183) is a chemotactic receptor, highly expressed by immune cells. Upon activation by its ligand, 7a,25-dihydroxycholesterol (7a,25-OHC), GPR183 activates downstream signals ......
Low Endotoxin Recovery: Wiederfindung und pyrogene Aktivität von Endotoxinen in pharmazeutischen Produkten
(2021-08-06)
Eine zuverlässige Überwachung bakterieller Kontaminationen ist entscheidend für die Herstellung und Sicherheit biopharmazeutischer Produkte. Die mikrobielle Sicherheit wird in der Regel (zusätzlich zu Sterilitätstests und ...
Exploration of bioresources enables detection and characterization of natural products with antibacterial activities and elucidation of the corresponding biosyntheses for derivative generation
(2021-11-17)
The discovery of antibiotics in the early 20th century sparked a medicinal revolution, which for the first time in history enabled humankind to effectively combat bacterial infections. Despite this immense success, the ...
Functional impact of Kir4.1 channels in hippocampal NG2 glia on neuronal plasticity and behavior
(2020-08-25)
NG2 glia represents the 4th type of CNS glial cells. In white matter, most of them differentiate into myelinating oligodendrocytes but in grey matter a majority retains their NG2 phenotype throughout life. Intriguingly, ...
Aptamer-mediated transactivation of transcription utilizing CRISPR/Cas9 and a photoreceptor
(2021-12-16)
In synthetic biology, spatio-temporal control of molecular functions is an essential tool for the investigation and manipulation of cellular processes. The usage of light enables a reversible non-invasive trigger, that ...