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Langerhans and inflammatory dendritic epidermal cells in atopic dermatitis tolerate Toll-like receptor 2-specific activation
(2021-01-26)
Atopic dermatitis (AD) is a chronic multifactorial inflammatory skin disease. The skin of AD patients shows a significant dysbalance of the microbiome with high colonization of S. aureus, which positively correlates with ...
State-dependent processing of Dentate Gyrus granule cell activity in-vivo
(2020-12-16)
The ability to form dissimilar neural activity patterns from similar sensory driven inputs is a phenomenon found in all vertebrates, called pattern separation. In mammals, pattern separation is closely related to a subregion ...
The influence of G-quadruplex structures on meiosis
(2021-01-27)
Several lines of evidence emphasize the potential function of G-quadruplex (G4) structures during DNA replication, transcription and recombination. Although there are experimental evidences that G4s play a role during ......
Effect of neural ablation of sphingosine-1-phosphate lyase (SGPL1) in glial cells
(2021-11-24)
Sphingosine-1-phosphate (S1P) is an evolutionarily conserved catabolic intermediate of sphingolipid metabolism that regulates diverse biological processes in the brain, including neural development, differentiation, and ...
Die Phyllosphäre als Lebensraum für Bakterien: Mechanismen der Interaktion epiphyller Bakterien mit der pflanzlichen Kutikula
(2020-12-16)
Die Phyllosphäre stellt einen lebensfeindlichen Lebensraum dar. Jedoch gibt es epiphytisch lebende Bakterien, die diesen Lebensumständen entgegenwirken und Mechanismen entwickelt haben, in diesem kargen Lebensraum Nährstoffe ......
Analyzing the Role of CyFIP2 in the Mouse Brain
(2020-06-19)
An important regulator of neuron outgrowth, growth cone motility and dendritic spine formation is the actin nucleator ARP2/3, a protein complex that functions in forming branched actin networks. ARP2/3 complex activity is ...
Neuroinvasion and cerebral ischemia as possible sources for α-synuclein prions in Parkinson’s disease
(2021-07-13)
In synucleinopathies such as Parkinson’s disease misfolding of α-synuclein, normally a cellular and soluble protein, leads to the accumulation of insoluble protein aggregates and to central nervous system disease (CNS). ...
Implementation of the novel high-throughput Fungal Isolation one step Device method FIND and secondary metabolite extraction from the isolate Heydenia cf. alpina
(2021-07-13)
Fungi are an important source of bioactive metabolites. The cultivation of source organisms is a crucial step in natural product isolation. With standard isolation methods for fungi it is difficult to isolate rare und ...
Function of Reelin Signaling in the Tangential Migration of Dopaminergic Neurons
(2021-01-07)
Midbrain dopaminergic neurons (mDA neurons) are involved in the regulation of voluntary movement, reward behavior and cognitive processes. mDA neurons are born in the floor plate of the ventral midbrain, from where they ...
Functional markers for cerebral norepinephrine deficiency in Alzheimer's disease
(2021-02-17)
Pathological alterations of the locus coeruleus (LC)-norepinephrine (NE) system occur early in the course of Alzheimer’s disease (AD), and manifest in poor attention and distractibility. Cortical NE is released from the ...