The Faculty of Mathematics and Natural Sciences: Search
Now showing items 21-29 of 29
Characterization of Ceramide synthase 2 dysfunctions caused by targeted mutations in transgenic mice
(2020-02-10)
Ceramide species are the precursor of sphingolipids, which serve as structural components of biological membranes or are bioactive molecules. In mammals, ceramides are synthesised by a family of ceramide synthases (CerS) ......
Locus coeruleus modulates locomotor activity via the medial septum and the diagonal band of Broca
(2020-10-02)
The locus coeruleus (LC) is positioned in the brainstem and one of the main sources of norepinephrine in the brain. With its projections throughout the whole brain, the LC plays an important role in regulating the general ...
Application of population, physiologically based, and semi-physiological pharmacokinetic modeling to assess sources of pharmacokinetic variability in individual drugs
(2020-06-05)
Large inter- and intra-individual variability in the response of drugs causes difficulties for clinicians to choose appropriate dosing regimens to target their therapeutic range. While underexposure might cause sub-therapeutic ...
Relevance of cGAMP-mediated bystander cell activation and cooperation of cGAS and TLR signaling in TREX1-related autoimmunity
(2020-11-05)
The aberrant recognition of endogenous nucleic acids by innate immune sensors can trigger a wide range of autoimmune and autoinflammatory conditions, mediated by type I interferons. Laoss-of-function mutations in the three ......
Bedeutung der cGAMP-vermittelten Bystander-Zellaktivierung und der Kooperation von cGAS- und TLR-Signalwegen bei TREX1-assoziierter Autoimmunität
Entwicklung von Autoinflammation und Autoimmune ......
Bedeutung der cGAMP-vermittelten Bystander-Zellaktivierung und der Kooperation von cGAS- und TLR-Signalwegen bei TREX1-assoziierter Autoimmunität
Entwicklung von Autoinflammation und Autoimmune ......
Direct lineage programming - a tool to generate and analyze human cortical layer specific neurons
(2020-05-14)
Until recently, lineage commitment and differentiation have been considered to be unidirectional and irreversible. This traditional view has dramatically changed with the advent of cellular reprogramming and direct cell ......
Functional in vivo calcium imaging in the hippocampus under healthy and disease conditions
(2020-04-22)
The hippocampus has long been known to be essential for all features of memory processing. Hippocampal function strongly depends on the orchestrated activity of transiently autonomous neuronal populations that create the ......
Creld1 controls T cell homeostasis in mouse and human
(2020-07-07)
Cysteine-rich with EGF-like domains 1 (Creld1) was recently found to be fundamental for the VEGF-mediated activation of NFATc1 during heart development. Creld1 complete KO in mice is lethal due to developmental problems ...
Fluorescent proteins for two-photon FLIM analysis of presynaptic protein interactions
(2020-06-10)
Monitoring Förster Resonance Energy Transfer (FRET) between fluorescent proteins (FPs) fused to proteins of interest is a powerful approach to study dynamic interactions of cellular proteins in living cells. The choice of ...
Activation Mechanisms of RIG-I
(2020-11-02)
(noch nicht zugänglich / not yet accessible)