Mathematisch-Naturwissenschaftliche Fakultät: Suche
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The enzyme HPGD is critical for regulatory T cell function in adipose tissue
(2020-02-06)
Regulatory T cells (Treg cells) are essential for maintaining immune homeostasis. However, how Treg cells exert their function in tissue specific environments is often unknown. We have found ......
Locus coeruleus modulates locomotor activity via the medial septum and the diagonal band of Broca
(2020-10-02)
The locus coeruleus (LC) is positioned in the brainstem and one of the main sources of norepinephrine in the brain. With its projections throughout the whole brain, the LC plays an important role in regulating the general ...
Pharmacokinetic-pharmacodynamic modeling of antibacterial agents in tissues and body fluids
(2020-11-25)
The aim of this thesis was to assess the pharmacokinetic / pharmacodynamics (PK/PD) of anti-bacterial agents in tissues and body fluids through non-linear mixed effects (NLME) modeling.
In the first project, a ...
In the first project, a ...
In situ observations of reaction and transport phenomena during silicate glass corrosion by fluid-cell Raman spectroscopy: Method development and applications
(2020-07-06)
Borosilicate glass is the preferred material for the immobilization of high-level nuclear waste and an important material for various industries. Silicate glasses, however, are prone to corrosion by aqueous solutions, which ......
Direct lineage programming - a tool to generate and analyze human cortical layer specific neurons
(2020-05-14)
Until recently, lineage commitment and differentiation have been considered to be unidirectional and irreversible. This traditional view has dramatically changed with the advent of cellular reprogramming and direct cell ......
On some Geometric Search Problems: Algorithms, Complexity, Computability
(2020-11-25)
This thesis considers four search problems which are related to or emerge from a geometric context. Each search problem is examined in a separate chapter; these four chapters are framed by an introduction and a conclusion ...
Design and Synthesis of A2B- and Dual-Acting A2A/A2B Adenosine Receptor Antagonists
(2020-10-27)
A2A and A2B adenosine receptors (ARs) are novel drug targets in cancer (immuno)therapy. Activation of A2AARs expressed on the surface of many immune cells such as T-lymphocytes and natural ...