The Faculty of Mathematics and Natural Sciences: Mathematisch-Naturwissenschaftliche Fakultät: Recent submissions
Now showing items 141-160 of 4984
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Development of intracellular ligands and targeted protein degraders for chemokine receptors and histone deacetylases
(2025-10-29)Chemokine receptors are a subfamily of G protein-coupled receptors (GPCRs) that play a crucial role in the immune system by regulating the migration and positioning of immune cells. They are involved in various physiological ... -
Investigation of BRD9 inhibition as alternative treatment option for testicular germ cell tumors
(2025-10-29)Type II germ cell tumors are the most prevalent tumor in young men between the ages of 15 and 35 years. They arise from a block in primordial germ cell differentiation leading to a precursor lesion called germ cell neoplasia ... -
Expanding cryospheric landform inventories: quantitative approaches for underestimated periglacial block- and talus slopes in the Dry Andes of Argentina
(2025-05-06)There is a clear spatial discrepancy between the area potentially underlain by permafrost and the landforms recorded in the national inventory of cryospheric landforms in the Dry Andes of Argentina (∼22°–35°S). In the ... -
From classrooms to real-world contexts: enhancing vaccine education through open schooling
(2025-01-29)The topic of vaccination has been a highly debated issue for many years, whether related to measles, HPV, or the recent COVID-19 pandemic. It necessitates deeper exploration, particularly in school biology classes where ... -
Improvement of Streamflow Forecasting for Flood Management and Mitigation in the White Volta Basin, Northern Ghana
(2025-10-24)Flooding in Ghana's White Volta basin has led to severe human displacement, fatalities, and extensive property damage. The region's heavy dependence on agriculture exacerbates these impacts, posing significant threats to ... -
Antibiotic-induced cellular effects in Wolbachia: Insights from cell wall biosynthesis inhibitors and corallopyronin A
(2025-10-24)(noch nicht zugänglich / not yet accessible) -
Pulsar timing and gravitational waves
(2025-10-23)Pulsars are magnetized rotating neutron stars that formed from the collapsed core of a massive star following a supernova. Charged particles are accelerated along the magnetic field lines producing electromagnetic radiation. ... -
Apolipoprotein E controls Dectin-1-dependent development of monocyte-derived alveolar macrophages upon pulmonary β-glucan-induced inflammatory adaptation
(2024-04-26)The lung is constantly exposed to the outside world and optimal adaptation of immune responses is crucial for efficient pathogen clearance. However, mechanisms that lead to lung-associated macrophages' functional and ... -
Structure-affinity and structure-residence time relationships of macrocyclic Gαq protein inhibitors
(2023-04-21)The macrocyclic depsipeptides YM-254890 (YM) and FR900359 (FR) are potent inhibitors of Gα<sub>q/11</sub> proteins. They are important pharmacological tools and have potential as therapeutic drugs. The hydrogenated, ... -
The Investigations on Diterpene Biosynthesis through Substrate and Protein Engineering
(2025-10-20)This cumulative doctoral dissertation "The Investigations on Diterpene Biosynthesis through Substrate and Protein Engineering" concentrates on diterpene biosynthesis from various aspects, including non-natural biotransformation, ... -
The Effects of Differential Constraints and Surface Energies on Scaling Laws for Singular Perturbation Problems
(2025-10-20)Motivated by mathematical models for phase transformations, arising, for example, in shape-memory alloys, and for micromagnetism in ferromagnetic materials, we study a class of A-free differential inclusions quantitatively. ... -
Low-Valent Heavier Tetrel Compounds Supported by N-heterocyclic Carbenes: A Comprehensive Experimental and Theoretical Perusal
(2025-10-17)(noch nicht zugänglich / not yet accessible) -
Generic Malware Unpacking: Existing Solutions, Requirements, New Approach for Windows Malware
(2025-10-17)Malware continues to be a substantial threat to cybersecurity, amplified by the widespread use of malicious executable packing, so-called packers. These packers inflate the number of unique samples in the wild by introducing ... -
Dimensional Crossover in a Photonic Quantum Gas
(2025-10-17)For many-body quantum systems, dimensionality is known to exert a profound influence on the physical behaviour, allowing for the shaping of distinct phases of matter. In general, for lower dimensions, enhanced fluctuations ... -
Proximity-based Therapeutic Modalities for Precise Modulation of Histone Deacetylases
(2025-10-17)Histone deacetylases (HDACs) serve as critical epigenetic regulators that modulate gene expression through catalytic removal of acetyl groups from histone substrates. By controlling the acetylation status of both histone ... -
On the Bäcklund transform and the stability of the line soliton of the KP-II equation on the plane
(2025-10-16)We provide a detailed study of the Bäcklund transform (or soliton addition map) of the KP-II equation on the Euclidean plane at critical regularity. The transform has the effect of superimposing a modulated line soliton ... -
Immune responses under hypoxic conditions
(2025-10-13)(noch nicht zugänglich / not yet accessible) -
Model-based design and the implementation of dosing and blending unit-operations for continuous direct compression
(2025-10-10)This thesis presents a comprehensive investigation and implementation of models for individual process units within a continuous dosing and blending module, aiming to support risk-based decision-making and data-driven ... -
An axis between brain and fat body regulates pathogen avoidance behavior in Drosophila
(2025-10-09)(noch nicht zugänglich / not yet accessible) -
Development of a GridPix-based X-ray Polarimeter
(2025-10-02)Measuring the polarisation of an electromagnetic wave can be a useful tool to study the emission source of the wave and the interactions of the wave during its propagation. While in the optical spectrum a measurement can ...
