The Faculty of Mathematics and Natural Sciences: Mathematisch-Naturwissenschaftliche Fakultät: Recent submissions
Now showing items 121-140 of 4981
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Total synthesis of Epicoccolide A & B and two related analogs
(2025-11-12)The family of epicoccolides has been known for over a decade now and show remarkable biological properties in a variety of fields. Different groups have reported antibacterial, antifungal and antitumor reactivity. More ... -
Unified Total Synthesis of Lysolipin Natural Products: Methodology and Bioactivity behind Polycyclic Aromatic Compounds
(2025-11-12)Lysolipin natural products are a family of bacterial polycyclic xanthones, renowned for their antibiotic potency and structural diversity. Yet, their complex architectures have long eluded synthetic access, and their ... -
Untersuchung zur mikrobiellen Produktion, Aufreinigung und Toxizität potenzieller Zuckerersatzstoffe
(2025-11-12)(noch nicht zugänglich / not yet accessible) -
Ingestion of micro- and nanoplastic perturbs tissue homeostasis and macrophage core functions
(2025-11-07)Plastic pollution has emerged as a global environmental crisis of unprecedented scale. Micro- and nanoplastic (MNP) pervade ecosystems, resulting in persistent exposure for all living organisms, including humans. MNP have ... -
Quantenchemische Berechnungen der Sauerstoffentwicklungsreaktion auf beschichteten Titandioxidoberflächen
(2025-11-07)In dieser Arbeit wurde mittels quantenchemischer Methoden nach alternativen Materialien als Katalysatoren für die Sauerstoffentwicklungsreaktion (OER) gesucht. Substituiertes Rutil-TiO<sub>2</sub> mit und ohne Monolagen- ... -
The impact of mechanical stretch on the stability of desmosomes in epithelia
(2025-11-07)The mechanoresponse of epithelia is a well-known and essential process. Both cytoskeleton and cell adhesion sites react to mechanical stimuli, e.g. mechanical stretch. Cell adhesions like desmosomes act as connection sites ... -
Influence of Cross Linking on the Stability of Functional Emulsion-Derived Polymer Films
(2025-11-04)(noch nicht zugänglich / not yet accessible) -
Data-Driven Strategies in Neurodegenerative Diseases: Advancing Drug Development and Disease Management
(2025-11-04)Neurodegenerative Disorders, including Alzheimer's, Parkinson's, and Huntington's Disease, pose major challenges to modern medicine due to their progressive nature and impact on patients and the healthcare system. These ... -
A Design Study for an Experiment to Search for Dark Photons at ELSA
(2025-11-03)This thesis presents a design study for proposed dark photon search experiment at the Electron Stretcher Accelerator ELSA in Bonn, called <span style="font-variant: small-caps;">Lohengrin</span>.<br/> Different proposed ... -
Hardware-Aware Quantum Optimization
(2025-11-03)Quantum Optimization (QO) is emerging as a promising approach to tackle hard combinatorial optimization problems by leveraging the unique computational properties of quantum hardware. In recent years, QO has gained traction ... -
Hydrogen Millimeter Recombination Lines as a Tracer of Extragalactic Star Formation Rates
(2025-11-03)When studying the structure and evolution of distant galaxies, the total star formation rate (SFR) of a given galaxy is an important observable. It is related to the gas, dust, and stellar mass content of a galaxy, and is ... -
Analysen zu intrazellulären Bakterien im Kontext des One-Health-Ansatzes
(2025-10-31)In dieser Dissertation wurden intrazelluläre bakterielle Erreger in Bezug auf deren Ausbreitung, antibiotische Therapie und Biologie untersucht. Der erste Teil der Arbeit befasste sich mit zoonotischen sowie neuartigen ... -
cOmicsArt: a customizable Omics Analysis and reporting tool
(2025-04-01)<strong>Motivation:</strong> The availability of bulk-omic data is steadily increasing, necessitating collaborative efforts between experimental and computational researchers. While software tools with graphical user ... -
Phosphatidylcholine synthesis and remodeling in brain endothelial cells
(2025-04)Mammalian cells synthesize hundreds of different variants of their prominent membrane lipid phosphatidylcholine (PC), all differing in the side chain composition. This batch is constantly remodeled by the Lands cycle, a ... -
Microglia and CD8+ T cell activation precede neuronal loss in a murine model of spastic paraplegia 15
(2025-04-23)In central nervous system (CNS) diseases characterized by late-onset neurodegeneration, the interplay between innate and adaptive immune responses remains poorly understood. This knowledge gap is exacerbated by the prolonged ... -
Structure and functional characterization of the B-domain and the full-length coagulation factor VIII
(2025-10-29)Factor VIII (FVIII) is a large glycoprotein that serves as a non-enzymatic cofactor for activated Factor IX, facilitating the proteolytic activation of Factor X in the coagulation cascade. Deficiency of FVIII leads to ... -
Periplectic and Isomeric Lie superalgebras, KLR algebras and Categorification
(2025-10-29)We explore the finite dimensional representation theory of the periplectic Lie superalgebra and the isomeric Lie superalgebr, focusing on explicit descriptions of their projective generators' endomorphism rings. Using ... -
Development of intracellular ligands and targeted protein degraders for chemokine receptors and histone deacetylases
(2025-10-29)Chemokine receptors are a subfamily of G protein-coupled receptors (GPCRs) that play a crucial role in the immune system by regulating the migration and positioning of immune cells. They are involved in various physiological ... -
Investigation of BRD9 inhibition as alternative treatment option for testicular germ cell tumors
(2025-10-29)Type II germ cell tumors are the most prevalent tumor in young men between the ages of 15 and 35 years. They arise from a block in primordial germ cell differentiation leading to a precursor lesion called germ cell neoplasia ... -
Expanding cryospheric landform inventories: quantitative approaches for underestimated periglacial block- and talus slopes in the Dry Andes of Argentina
(2025-05-06)There is a clear spatial discrepancy between the area potentially underlain by permafrost and the landforms recorded in the national inventory of cryospheric landforms in the Dry Andes of Argentina (∼22°–35°S). In the ...
