The Faculty of Mathematics and Natural Sciences: Mathematisch-Naturwissenschaftliche Fakultät: Recent submissions
Now showing items 101-120 of 4736
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Aufklärung von Resistenzmechanismen gegen Cisplatin und PARP-Inhibitoren in Ovarialkarzinomzellen mit besonderem Fokus auf Signalwegen der Redox Homöostase und DNA Reparatur
(2024-11-28)Ovarialkarzinome unterliegen einer hohen Resistenzbildungsrate, die in der Klinik häufig zum Tod der Patientinnen führt. Zur Aufklärung von Mechanismen der Toleranz gegen das etablierte Zytostatikum Cisplatin werden zunächst ... -
Wild pollination in agroecosystems with a focus on Brachycera and Hymenoptera: an integrative approach
(2024-11-26)(noch nicht zugänglich / not yet accessible) -
Dissecting Synaptogenesis and Axonal Branching Mechanisms in Drosophila Melanogaster
(2024-11-25)Axonal branching and synaptogenesis are critical mechanisms in neuronal development, enabling the formation of complex neural communication networks. Despite their importance, the specific regulatory factors and signaling ... -
Characterization of the TJ-Monopix2 Depleted Monolithic Active Pixel Sensor for High-Energy Physics Experiments
(2024-11-22)Monolithic pixel detectors demonstrate an advancement in the field of particle detectors, offering high spatial resolution and low material budget. With the availability of highly resistive silicon substrates and high-voltage ... -
Structural and Functional Investigation of a Type III CRISPR Immune Pathway and
(2024-11-21)
a Bacterial Sialic Acid TRAP Transporter Multiple mechanisms have evolved to protect organisms from invaders. These immune strategies vary widely in complexity, specificity, response time, and long-term protection. While all types of immune systems continuously ... -
Yield Prediction with Explainable Machine Learning
(2024-11-21)Starting from a federal project to predict grapevine yields in Germany, we faced five challenges to enable machine learning for yield prediction. The first challenge is training on small data sets, as capturing data for ... -
Instance Segmentation, Tracking and Action Detection of Animals in Wildlife Videos
(2024-11-19)Monitoring animal species efficiently in their natural habitats is essential to describe and analyze the development of ecosystems and populations and to detect the causes of changes due to climate change or other external ... -
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Mathematical theory for multi-dimensional coagulation models
(2024-11-13)In this thesis, we consider problems that appear in the study of coagulation models. Coagulation equations describe the evolution in time of a system of particles that are characterized by their volume. The focus of this ... -
ATLAS ITk Silicon Strip Detector Performance Studies based on the System Test with Cosmic Muons at DESY
(2024-11-13)The ATLAS experiment is the world’s largest collider-based particle physics experiment, located at the LHC in Geneva. An upgrade of the LHC will greatly increase the radiation environment and track density in the inner ... -
Distributed Anomaly Detection on Large Knowledge Graphs
(2024-11-12)Digitization has yielded vast data, known as Big Data, fostering data analysis. As this data comes from various sources and is of diverse types, data integration techniques become essential in making analytics more accessible ... -
Molecular level insight to solvents: From understanding, via media effects, to developing a Hybrid Monte Carlo code
(2024-11-12)With the increasing demand for resources in modern society and the impacts of climate change, there is a growing need for innovative and environmentally friendly solutions. Achieving sustainability in chemistry and materials ... -
Synthese und Charakterisierung von Zimmermann-Fischer-Kondensaten
(2024-11-11)Gegenstand der vorliegende Arbeit ist eine umfassende Untersuchung der <em>Zimmermann-Fischer</em>-Kondensation und seiner Produkte. <br /> Im ersten Teil der Arbeit wurde eine theoretische Betrachtung des Mechanismus ... -
Synthese neuer molekularer Abstandshalter zur Adsorption auf Festkörperoberflächen
(2024-11-11)Im Rahmen dieser Arbeit wurden neue definierte Makrozyklen (MZ) präsentiert, die durch ihre in drei lateralen Richtungen vororientierten Alkoxy-Seitenketten eine vorhersagbare Parkettierung der HOPG-Oberfläche an der ... -
Synthesis and chemistry of P-bridged, bent and planar bis(N-heterocyclic) carbenes
(2024-11-08)This PhD thesis focuses on the synthesis of new 7,8-dihydro-1,4-diphosphabarrelenes and their subsequent conversion into the corresponding P-bridged bis(imidazolium) salts and bis(N-heterocyclic) carbenes (bis(NHCs)).<br ... -
Untersuchungen zur heterologen Biosynthese des seltenen kompatiblen Soluts Nε-Acetyl-β-Lysin
(2024-11-07)Das Aminosäurederivat N<sub>ε</sub>-Acetyl-β-Lysin (NAβL) wird von methanogenen Archaeen und einigen Vertretern der Bakterien zur Anpassung an osmotischen Stress produziert. Bisher wurden vor allem die zur Produktion ... -
Role of the AhR-Repressor and AhR-dependent CYP1 Monooxygenases in Immune Cells Regulation
(2024-11-05)The Aryl hydrocarbon receptor (AhR) is a transcription factor that can be activated by various polyaromatic ligands and plays an important role in immune regulatory processes. AhR activity is regulated through the AhR-repressor ... -
Characterization of a PEM electrolyzer for ozone generation in ultrapure and drinking water applications
(2024-10-31)The electrolytic in situ generation of oxidants is an increasingly widespread technique for producing sanitized and thus safe process water in ultrapure water distribution systems. In particular, the anodic production of ... -
P and S-centred reactions in a thiazole-fused 1,4-diphosphinine: insights into addition and redox chemistry
(2024-10-31)Starting from a tricyclic, thiazole-2-thione-based 1,4-diphosphinine, the scope of both P- and S-functionalisations was explored. 1,4-addition reactions at the central ring were investigated, furnishing 1,4-dihydro-1,4-d ... -
Peptidomimetics in Drug Development: Substrates, Titrants, and Inhibitors to Study and Combat SARS-CoV-2 and Proteolysis Targeting Chimeras as 18F-Tracers
(2024-10-31)This thesis provides a profound contribution to the application spectrum of peptidomimetics in the drug discovery process. It demonstrates the exploration of the main protease (M<sup>pro</sup>) of SARS-CoV-2 through ...
