The Faculty of Mathematics and Natural Sciences: Mathematisch-Naturwissenschaftliche Fakultät: Recent submissions
Now showing items 961-980 of 5029
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Multiple Objective Learning for Effective Knowledge Graph Embedding
(2023-03-15)Over the past decade, knowledge graphs (KGs) have become popular for capturing structured domain knowledge. Knowledge graphs particularly allow the effortless integration of heterogeneous data into a coherent model. Besides ... -
Kooperative Titan/Chrom-Katalysatorsysteme zur Synthese von anti-Markownikow-Alkoholen
(2023-03-14)Zur Synthese von anti-Markownikow-Alkoholen bietet das in dieser Arbeit entwickelte kooperative Katalysatorsystem aus Titan und Chrom eine wirkungsvolle Alternative zu herkömmlichen Methodiken. <br /> Dabei ist die ... -
The mesoscale organization of Syntaxin 1A and SNAP25 at the plasma membrane
(2023-03-09)The plasma membrane is a highly crowded place consisting of a plethora of proteins and lipids, which show a high degree of micropatterning. Most proteins are not homogeneously distributed but concentrated in clusters. ... -
Silicon Compounds in Low Oxidation States Supported by a Cyclic (Alkyl)(Amino)Carbene: Synthesis, Structure and Reactivity
(2023-03-09)<strong>Abstract:</strong> Silicon compounds in low oxidation states, especially dihalosilylenes (SiX<sub>2</sub>), are highly unstable molecules, which are involved as fleeting intermediates in the industrial production ... -
Identification of Genetic Risk Variants for the Development of Gastric Adenocarcinoma
(2023-03-07)Gastric cancer (GC) is a clinically heterogeneous and one of the most common malignant tumour entities affecting the human gastrointestinal tract with a multifactorial aetiology. Beside environmental risk factors, also ... -
Modeling of Ewaso Narok floodplain: a study of the hydrochemistry and hydrogeology in a data scarce environment
(2023-03-07)The Ewaso Narok wetland, a floodplain intensively used for grazing, drinking, and agriculture, is part of Kenya’s largest drainage basin. This study lies within the water and food security scope, in affiliation with the ... -
Inhibition of heterotrimeric Gs proteins by FR900359 - more than a simple transfer of the inhibitor binding site
(2023-03-07)A plethora of vital functions of the human body, including blood pressure, cell proliferation and metabolism are regulated by G protein-mediated signaling cascades. These cascades form a complex network of cause and effect ... -
Measurement of Lepton Mass Squared Moments of B→Xclνl Decays with the Belle II Experiment and Determination of the CKM Matrix Element |Vcb|
(2023-03-07)This thesis presents measurements of the first to fourth moments of the lepton mass squared q<sup>2</sup>=(p<sub>l</sub> + p<sub>ν</sub>)<sup>2</sup> distribution of B→X<sub>c</sub>lν decays for l=e,μ and with X<sub>c</sub> ... -
Pharmacometric modeling of fluoropyrimidines
(2023-03-07)The fluoropyrimidine drugs fluorouracil (5FU) and capecitabine are widely used for the treatment of various solid tumors. Despite the long-term clinical experience with these drugs a substantial proportion of patients is ... -
Biochemical and structural studies of NOD-like receptors and their inhibition by small molecule inhibitors
(2023-03-07)NOD-like receptors (NLRs) are innate immune sensors that can form inflammasomes driving pyroptosis. NLRP3 is the best studied member of the NLRs to date, and its dysregulation has been linked to human diseases relevant to ... -
Converting the elusive G protein-coupled adenosine A3 receptor into a highly-stable, well-characterized receptor model for structural studies
(2023-03-06)The G protein-coupled adenosine A3 receptor (A3AR) is widely expressed in the human body, with the highest expression levels found in lung and liver. The receptor is involved in a number of pathological processes, e.g., ... -
Metastability of the Ising model with random interaction coefficients
(2023-02-24)In this Ph.D. thesis we present results on metastability of random modifications of Ising spin systems which evolve with Glauber dynamics. Their Hamiltonians have random and possibly inhomogeneous interaction coefficients. ... -
Interesse an Insekten fördern: Eine Design-Based Research Studie mit Jugendlichen
(2023-02-23)Um den Herausforderungen des Rückgangs von Insekten zu begegnen ist es von Bedeutung, das Interesse an Insekten zu fördern. Interesse ist eine wichtige Lernvoraussetzung und zentral für die Bereitschaft, Biodiversität zu ... -
Biochemische Analyse der Interaktion von P2X4 und P2X7 und Charakterisierung von P2X7B und genetisch verlinkten P2X4/P2X7-Konkatameren
(2023-02-23)Das übergeordnete Ziel meiner Arbeit war die Untersuchung der Interaktion von P2X7 und P2X4. Zur Identifikation von potenziellen Interaktionspartnern habe ich den P2X7-Rezeptors von Mensch und Ratten mit den weiteren ... -
Analysis of the physiological response of perivascular adipose tissue during cold exposure
(2023-02-22)Aortic valve disease (AVD) is common for people over 65 and its severity increases with age. Aortic aneurysm (AA) is the tenth cause of death for men above 55. Its prevalence was estimated to be up to 8.9% for men and up ... -
Mechanical strain influence on functional signaling of neurons in vitro
(2023-02-22)Neuronal cells are embedded in the soft brain tissue and are protected by the thick meninges, as well as the rigid skull bones. Despite being highly sensitive and vastly protected, neurons are prone to internal and external ... -
Towards Practical Real-time Reflectance Estimation
(2023-02-22)Virtual experiences are becoming increasingly popular, primarily due to tremendous progress in Virtual Reality (VR) and Augmented Reality (AR) technologies improving immersion and making related devices more affordable. ... -
Intraarticular pharmacokinetics of biologics and drug-delivery strategies to extend transsynovial permeation
(2023-02-21)A local injection is often considered the only appropriate route of administration for active pharmaceutical ingredients that cannot cross biomembranes easily or that are not sufficiently stable in the gastrointestinal ... -
Targeted transport of active pharmaceutical ingredients into adipose tissue
(2023-02-21)Adipose tissue (AT) plays an essential role in controlling metabolic activities. White adipose tissue (WAT) stores energy and possesses endocrine functions, while brown adipose tissue (BAT) is responsible for energy ... -
Neuartige Oxidphosphate (M,M’)OPO4 (M,M’: V, Nb, Ta, W, Sb): Ab initio Modellierung, Synthese, Charakterisierung und Redoxverhalten
(2023-02-14)Die vorliegende Arbeit befasst sich mit der Synthese, Charakterisierung und ab initio Modellierungen von den Oxidphosphaten MOPO<sub>4</sub>. Als Synthesemethode wurde hierbei schwerpunktmäßig die Solution Combustion ...
