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Second-line and third-line therapy with nanoliposomal irinotecan (nal-IRI) in pancreatic cancer: a single-center experience and review of literature
Möhring, Christian; Frontado Graffe, Freddy José; Bartels, Alexandra; Sadeghlar, Farsaneh; Zhou, Taotao; Mahn, Robert; Marinova, Milka; Feldmann, Georg; Brossart, Peter; Glowka, Tim; Kalff, Jörg; Strassburg, Christian; Gonzalez-Carmona, Maria (2023-02-15)Background: Prognosis of patients with pancreatic cancer is still extremely poor. First-line palliative therapies with FOLFIRINOX or gemcitabine/nab-paclitaxel have been established in the last decade. In the second-line, ... -
UDP-glucuronosyltransferase polymorphisms affect diethylnitrosamine-induced carcinogenesis in humanized transgenic mice
Landerer, Steffen; Kalthoff, Sandra; Paulusch, Stefan; Strassburg, Christian P. (2020-08-28)UDP-glucuronosyltransferase (UGT) 1A enzymes detoxify a broad array of exogenous compounds including environmental toxins and carcinogens. Case-control studies identified genetic variations in UGT1A genes leading to reduced ...